{"doi":"10.17615/fxbm-xy63","title":"Chronic Periodontitis Genome-wide Association Study in the Hispanic Community Health Study / Study of Latinos","abstract":"Chronic periodontitis (CP) has a genetic component, particularly its severe forms. Evidence from genome-wide association studies (GWASs) has highlighted several potential novel loci. Here, the authors report the first GWAS of CP among a large community-based sample of Hispanics/Latinos. The authors interrogated a quantitative trait of CP (mean interproximal clinical attachment level determined by full-mouth periodontal examinations) among 10,935 adult participants (mean age: 45 y, range: 18 to 76 y) from the Hispanic Community Health Study / Study of Latinos. Genotyping was done with a custom Illumina Omni2.5M array, and imputation to approximately 20 million single-nucleotide polymorphisms was based on the 1000 Genomes Project phase 1 reference panel. Analyses were based on linear mixed models adjusting for sex, age, study design features, ancestry, and kinship and employed a conventional P < 5 × 10−8 statistical significance threshold. The authors identified a genome-wide significant association signal in the 1q42.2 locus (TSNAX-DISC1 noncoding RNA, lead single-nucleotide polymorphism: rs149133391, minor allele [C] frequency = 0.01, P = 7.9 × 10−9) and 4 more loci with suggestive evidence of association (P < 5 × 10−6): 1q22 (rs13373934), 5p15.33 (rs186066047), 6p22.3 (rs10456847), and 11p15.1 (rs75715012). We tested these loci for replication in independent samples of European-American (n = 4,402) and African-American (n = 908) participants of the Atherosclerosis Risk in Communities study. There was no replication among the European Americans; however, the TSNAX-DISC1 locus replicated in the African-American sample (rs149133391, minor allele frequency = 0.02, P = 9.1 × 10−3), while the 1q22 locus was directionally concordant and nominally significant (rs13373934, P = 4.0 × 10−2). This discovery GWAS of interproximal clinical attachment level—a measure of lifetime periodontal tissue destruction—was conducted in a large, community-based sample of Hispanic/Latinos. It identified a genome-wide significant locus that was independently replicated in an African-American population. Identifying this genetic marker offers direction for interrogation in subsequent genomic and experimental studies of CP.","journal":"UNC Libraries","year":2020,"id":139921,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9195,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":604098,"name":"Salazar","orcid":null,"position":1,"is_corresponding":false},{"id":604099,"name":"Agler,","orcid":null,"position":2,"is_corresponding":false},{"id":604100,"name":"Sofer,","orcid":null,"position":3,"is_corresponding":false},{"id":604101,"name":"Singer","orcid":null,"position":4,"is_corresponding":false},{"id":604102,"name":"Wong,","orcid":null,"position":5,"is_corresponding":false},{"id":604103,"name":"North,","orcid":null,"position":6,"is_corresponding":false},{"id":604104,"name":"Cai,","orcid":null,"position":7,"is_corresponding":false},{"id":604105,"name":"Beck,","orcid":null,"position":8,"is_corresponding":false},{"id":604106,"name":"Kerr,","orcid":null,"position":9,"is_corresponding":false},{"id":604107,"name":"Laurie,","orcid":null,"position":10,"is_corresponding":false},{"id":604108,"name":"Divaris,","orcid":null,"position":11,"is_corresponding":false},{"id":604109,"name":"Shaffer,","orcid":null,"position":13,"is_corresponding":false},{"id":276558,"name":"Sanders,","orcid":null,"position":14,"is_corresponding":false},{"id":604110,"name":"Divaris","orcid":null,"position":15,"is_corresponding":false},{"id":604097,"name":"Finlayson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:13.583586Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}