{"doi":"10.17615/fjt5-hw03","title":"Phenolic Diterpenoid Derivatives as Anti-Influenza A Virus Agents","abstract":"A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.","journal":"Figshare","year":2020,"id":135072,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":540035,"name":"Kuo Hsiung Lee","orcid":null,"position":1,"is_corresponding":false},{"id":591767,"name":"Katherine Jung","orcid":null,"position":2,"is_corresponding":false},{"id":589736,"name":"Huang Li","orcid":"0000-0003-4154-818X","position":3,"is_corresponding":false},{"id":540034,"name":"Chin Ho Chen","orcid":null,"position":4,"is_corresponding":false},{"id":591768,"name":"Zhu, Lei","orcid":null,"position":5,"is_corresponding":false},{"id":590609,"name":"Hua Xie","orcid":"0000-0003-2091-6457","position":6,"is_corresponding":false},{"id":395053,"name":"Zhao Dang","orcid":"0009-0002-2313-6667","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:27.963294Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}