{"doi":"10.17615/fhee-es55","title":"The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction","abstract":"Carcinoembryonic antigen cell adhesion molecule like I (CEACAM1) is expressed on activated T cells and signals through either a long (L) cytoplasmic tail containing immune receptor tyrosine based inhibitory motifs, which provide inhibitory function, or a short (S) cytoplasmic tail with an unknown role. Previous studies on peripheral T cells show that CEACAM1-L isoforms predominate with little to no detectable CEACAM1-S isoforms in mouse and human. We show here that this was not the case in tissue resident T cells of intestines and gut associated lymphoid tissues which demonstrated predominant expression of CEACAM1-S isoforms relative to CEACAM1-L isoforms in human and mouse. This tissue resident predominance of CEACAM1-S expression was determined by the intestinal environment where it served a stimulatory function leading to the regulation of T cell subsets associated with generation of secretory IgA immunity, the regulation of mucosal commensalism, and defense of the barrier against enteropathogens.","journal":"UNC Libraries","year":2020,"id":144590,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237266,"name":"Christian Jobin","orcid":"0000-0002-3733-1001","position":1,"is_corresponding":false},{"id":294491,"name":"Shuhei Hosomi","orcid":"0000-0002-8808-5672","position":2,"is_corresponding":false},{"id":613695,"name":"Kathryn V. Holmes","orcid":null,"position":3,"is_corresponding":false},{"id":329976,"name":"Kristi Baker","orcid":"0000-0002-2993-3889","position":4,"is_corresponding":false},{"id":613020,"name":"Nicole Beauchemin","orcid":"0000-0002-7445-8765","position":5,"is_corresponding":false},{"id":613696,"name":"Elizabeth M. Halvorsen","orcid":null,"position":6,"is_corresponding":false},{"id":568407,"name":"Lanfen Chen","orcid":"0000-0002-9413-1284","position":7,"is_corresponding":false},{"id":270825,"name":"Janelle C. Arthur","orcid":"0000-0002-4796-0207","position":8,"is_corresponding":false},{"id":613021,"name":"Andre Pires da Cunha","orcid":"0000-0002-8773-3420","position":9,"is_corresponding":false},{"id":23354,"name":"Joshua W. K. Ho","orcid":"0000-0003-2331-7011","position":10,"is_corresponding":false},{"id":613022,"name":"Darren E. Higgins","orcid":"0000-0003-0562-1300","position":11,"is_corresponding":false},{"id":613023,"name":"G. B. Gerber","orcid":"0000-0002-6767-7118","position":12,"is_corresponding":false},{"id":282854,"name":"Zhangguo Chen","orcid":"0000-0002-2741-0080","position":13,"is_corresponding":false},{"id":613697,"name":"Ken J. Dery","orcid":null,"position":14,"is_corresponding":false},{"id":576422,"name":"Yu‐Hwa Huang","orcid":null,"position":15,"is_corresponding":false},{"id":558638,"name":"Andrew B. Onderdonk","orcid":"0000-0001-8998-8972","position":16,"is_corresponding":false},{"id":298482,"name":"Lynn Bry","orcid":"0000-0002-8792-8527","position":17,"is_corresponding":false},{"id":605700,"name":"Magdalena B. Flak","orcid":"0000-0002-8238-9835","position":18,"is_corresponding":false},{"id":7840,"name":"Howard L. Weiner","orcid":"0000-0003-0203-9681","position":19,"is_corresponding":false},{"id":289783,"name":"John E. Shively","orcid":"0000-0002-7763-770X","position":20,"is_corresponding":false},{"id":262528,"name":"Richard S. Blumberg","orcid":"0000-0002-9704-248X","position":21,"is_corresponding":false},{"id":590368,"name":"Takashi Nagaishi","orcid":"0000-0002-9360-0405","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:45.339291Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}