{"doi":"10.17615/fcfx-de32","title":"Substance use and menopausal symptoms among people with and without HIV in the US, 2008-2020","abstract":"OBJECTIVE: The aim of the study is to assess associations between substance use and menopausal symptoms among US people living with and without HIV in a longitudinal cohort. METHODS: We analyzed self-reported menopausal symptoms and substance use from biannual Women's Interagency HIV Study (WIHS) visits from 2008-2020. Substance use since the last visit or lifetime cumulative use included tobacco, alcohol, marijuana, crack/cocaine, and opioids. Logistic regression quantified associations between each substance use and menopausal symptom frequency (vasomotor, mood, and musculoskeletal), adjusting for other substance use, HIV status, demographics, comorbidities, and trauma. RESULTS: A total of 1,949 participants contributed early perimenopausal, late perimenopausal, or postmenopausal study visits. Across reproductive-aging stages, based on menstrual history, and among participants with and without HIV, participants reported frequent vasomotor (range 22-43%), mood (18-28%), and musculoskeletal (25-34%) symptoms. Many reported ever using tobacco (72%), heavy alcohol (75%), marijuana (73%), crack (50%), and opioids (31%). Current heavy alcohol use (odds ratio [OR]: 1.22; 95% confidence interval [CI]: 1.10-1.37), cumulative marijuana use (OR: 1.15, 95% CI: 1.01-1.32), and cumulative tobacco use (OR: 1.06, 95% CI: 1.01-1.12) were associated with a higher frequency of vasomotor symptoms; current heavy alcohol use (OR: 1.20, 95% CI: 1.04-1.39) and current opioid use (OR: 1.13; 95% CI: 1.01-1.25) were associated with mood symptoms; and current opioid use (OR: 1.11, 95% CI: 1.00-1.23) was associated with musculoskeletal symptoms. All other associations were found to be null. CONCLUSIONS: Current and prior substance use may independently affect symptoms experienced during the menopausal transition and may indicate potential to benefit from additional intervention and referral to menopause specialty care.","journal":"UNC Libraries","year":2025,"id":576852,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7759,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":329431,"name":"Andrew Edmonds","orcid":"0000-0001-6768-0096","position":1,"is_corresponding":false},{"id":732879,"name":"Brooke W. Bullington","orcid":"0000-0002-3341-087X","position":2,"is_corresponding":false},{"id":1486112,"name":"Topper, Elizabeth F.","orcid":null,"position":3,"is_corresponding":false},{"id":340367,"name":"Lisa Rahangdale","orcid":"0000-0002-4444-7969","position":4,"is_corresponding":false},{"id":1190551,"name":"Helen E. Cejtin","orcid":"0000-0002-9151-0203","position":5,"is_corresponding":false},{"id":446286,"name":"Dominika Seidman","orcid":null,"position":6,"is_corresponding":false},{"id":402355,"name":"Tracey E. Wilson","orcid":"0000-0002-2087-8545","position":7,"is_corresponding":false},{"id":334762,"name":"Catalina Ramirez","orcid":"0000-0002-0872-0307","position":8,"is_corresponding":false},{"id":1316247,"name":"Seble G. Kasseye","orcid":null,"position":9,"is_corresponding":false},{"id":414456,"name":"Caitlin A. Moran","orcid":"0000-0001-8436-0465","position":10,"is_corresponding":false},{"id":301953,"name":"Adaora A. Adimora","orcid":"0000-0001-5035-1552","position":11,"is_corresponding":false},{"id":878081,"name":"Genevieve Neal-Perry","orcid":null,"position":12,"is_corresponding":false},{"id":376395,"name":"Andrea K. Knittel","orcid":"0000-0002-4292-3255","position":13,"is_corresponding":false},{"id":391094,"name":"Deborah L. Jones","orcid":"0000-0002-4106-8891","position":14,"is_corresponding":false},{"id":763068,"name":"Anjali Sharma","orcid":"0000-0002-3909-3174","position":15,"is_corresponding":false},{"id":404729,"name":"Deborah Konkle‐Parker","orcid":"0000-0002-3319-8442","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:58:00.620755Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}