{"doi":"10.17615/f32k-tf55","title":"A microRNA polycistron as a potential human oncogene","abstract":"To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17–92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas1. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17–92 locus are often substantially increased in these cancers. Enforced expression of the mir-17–92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17–92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17–92 cluster as a potential human oncogene.","journal":"UNC Libraries","year":2020,"id":49357,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":265,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":103970,"name":"Scott Powers","orcid":"0000-0003-2769-1932","position":1,"is_corresponding":false},{"id":13006,"name":"Carlos Cordon‐Cardo","orcid":"0000-0003-0858-5624","position":2,"is_corresponding":false},{"id":237544,"name":"Lin He","orcid":"0000-0003-1079-1195","position":3,"is_corresponding":false},{"id":228666,"name":"Eva Hernando","orcid":"0000-0003-1023-0312","position":4,"is_corresponding":false},{"id":237545,"name":"David Mu","orcid":"0000-0002-7762-0182","position":5,"is_corresponding":false},{"id":11809,"name":"Gregory J. Hannon","orcid":"0000-0003-4021-3898","position":6,"is_corresponding":false},{"id":35369,"name":"Michael T. Hemann","orcid":"0000-0001-6776-2163","position":7,"is_corresponding":false},{"id":239170,"name":"J. Michael Thomson","orcid":null,"position":8,"is_corresponding":false},{"id":239171,"name":"Scott M. Hammond","orcid":null,"position":9,"is_corresponding":false},{"id":218307,"name":"Scott W. Lowe","orcid":"0000-0002-5284-9650","position":10,"is_corresponding":false},{"id":239169,"name":"Summer Goodson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T20:36:25.163232Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}