{"doi":"10.17615/f2jn-m070","title":"Potential Autonomic Risk Factors for Chronic TMD: Descriptive Data and Empirically Identified Domains from the OPPERA Case-Control Study","abstract":"Several case-control studies have been conducted that examine the association between autonomic variables and persistent pain conditions; however, there is a surprising dearth of published studies in this area that have focused on temporomandibular disorders (TMD). The current study presents autonomic findings from the baseline case-control study of the OPPERA (Orofacial Pain: Prospective Evaluation and Risk Assessment) cooperative agreement. Measures of arterial blood pressure, heart rate, heart rate variability, and indirect measures of baroreflex sensitivity were assessed at rest and in response to a physical (orthostatic) and psychological (Stroop) stressors in 1633 TMD-free controls and 185 TMD cases. In bivariate and demographically adjusted analyses, greater odds of TMD case status were associated with elevated heart rates, reduced heart rate variability, and reduced surrogate measures of baroreflex sensitivity across all experimental procedures. Principal component analysis was undertaken to identify latent constructs revealing five components. These findings provide evidence of associations between autonomic factors and TMD. Future prospective analyses in the OPPERA cohort will determine if the presence of these autonomic factors predicts increased risk for developing new onset TMD.","journal":"UNC Libraries","year":2020,"id":143141,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8682,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":301593,"name":"Richard Ohrbach","orcid":"0000-0002-9266-9734","position":1,"is_corresponding":false},{"id":79748,"name":"Eric Bair","orcid":"0000-0001-8733-7869","position":2,"is_corresponding":false},{"id":393555,"name":"Luda Diatchenko","orcid":"0000-0002-1350-6727","position":3,"is_corresponding":false},{"id":449337,"name":"Vanessa Miller","orcid":"0000-0003-3537-649X","position":4,"is_corresponding":false},{"id":301597,"name":"Gary D. Slade","orcid":"0000-0002-4065-6341","position":5,"is_corresponding":false},{"id":541052,"name":"Charles Knott","orcid":"0000-0002-3340-1850","position":6,"is_corresponding":false},{"id":279185,"name":"Flora Mulkey","orcid":"0000-0003-0760-2648","position":7,"is_corresponding":false},{"id":130820,"name":"William Maixner","orcid":null,"position":8,"is_corresponding":false},{"id":301594,"name":"Joel D. Greenspan","orcid":"0000-0003-4062-9797","position":9,"is_corresponding":false},{"id":276565,"name":"Ronald Dubner","orcid":null,"position":10,"is_corresponding":false},{"id":301592,"name":"Roger B. Fillingim","orcid":"0000-0002-7699-8183","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:38.432803Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}