{"doi":"10.17615/ebd9-pa93","title":"IGF-I improved bone mineral density and body composition of weaver mutant mice","abstract":"Our recent report on a parallel decrease in the body weights and serum IGF-I levels of weaver mice suggests that IGF-I’s endocrine function may be impaired in neurodegenerative diseases. To further understand the overall effects of IGF-I deficiency on the postnatal growth, we measured bone mineral density (BMD), bone mineral content (BMC), lean body mass (LBM) and fat mass in male and female weaver mice and wild-type littermates on D21 (prepuberty), D45 (puberty), and D60 (postpuberty) using Dual-Energy X-ray Absorptionmetry (DEXA). In both male and female weaver mice, we found that the levels of circulating IGF-I paralleled those of BMD, BMC, and LBM, but not the fat mass. Male weaver mice have normal fat mass at all three ages studied, whereas female weaver mice showed a trend to increase their fat mass as they mature. To determine whether circulating IGF-I is a determinant of body composition, we crossbred IGF-I transgenic mice with homozygous weaver mice, which resulted in a significant increase in circulating IGF-I levels in both male and female weaver mice and normalization of their BMD, BMC and body weights. In summary, our results demonstrated that normal circulating IGF-I levels are important in maintaining BMD, BMC, and body composition in neurodegenerative diseases, such as hereditary cerebellar ataxia.","journal":"UNC Libraries","year":2020,"id":137197,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":597738,"name":"Therry Warner","orcid":null,"position":1,"is_corresponding":false},{"id":597200,"name":"Tomica Božić","orcid":"0000-0002-1216-434X","position":2,"is_corresponding":false},{"id":597201,"name":"Jun Yu","orcid":"0000-0002-9653-0422","position":3,"is_corresponding":false},{"id":547054,"name":"Zhong Jin","orcid":"0000-0001-8860-8579","position":4,"is_corresponding":false},{"id":597739,"name":"A. Joseph D’Ercole","orcid":null,"position":5,"is_corresponding":false},{"id":597740,"name":"Weiguo Yao","orcid":null,"position":6,"is_corresponding":false},{"id":597202,"name":"Ping Ye","orcid":"0000-0002-6624-0627","position":7,"is_corresponding":false},{"id":597741,"name":"Janet. M. Hock","orcid":null,"position":8,"is_corresponding":false},{"id":597737,"name":"Wei-Hua Lee","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:56.001887Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}