{"doi":"10.17615/e8mc-ev77","title":"Multi-Modal Imaging with a Toolbox of Influenza A Reporter Viruses","abstract":"Reporter viruses are useful probes for studying multiple stages of the viral life cycle. Here we describe an expanded toolbox of fluorescent and bioluminescent influenza A reporter viruses. The enhanced utility of these tools enabled kinetic studies of viral attachment, infection, and co-infection. Multi-modal bioluminescence and positron emission tomography–computed tomography (PET/CT) imaging of infected animals revealed that antiviral treatment reduced viral load, dissemination, and inflammation. These new technologies and applications will dramatically accelerate in vitro and in vivo influenza virus studies.","journal":"UNC Libraries","year":2020,"id":110848,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":527956,"name":"Daniel S. Poole","orcid":null,"position":1,"is_corresponding":false},{"id":5953,"name":"Timothy P. Sheahan","orcid":"0000-0001-9181-2183","position":2,"is_corresponding":false},{"id":527957,"name":"Aleksey Yevtodiyenko","orcid":null,"position":3,"is_corresponding":false},{"id":526986,"name":"Vy Anh Tran","orcid":"0000-0001-5533-8381","position":4,"is_corresponding":false},{"id":527958,"name":"Shiyun You","orcid":null,"position":5,"is_corresponding":false},{"id":527959,"name":"Justin J. Jeffrey","orcid":null,"position":6,"is_corresponding":false},{"id":481322,"name":"Andrew Mehle","orcid":"0000-0001-6060-4330","position":7,"is_corresponding":false},{"id":527960,"name":"Donald Creech","orcid":null,"position":8,"is_corresponding":false},{"id":363847,"name":"Kevin P. Francis","orcid":"0000-0002-3473-0429","position":9,"is_corresponding":false},{"id":526985,"name":"Andrew J. Peat","orcid":"0000-0003-4351-5541","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:01.914939Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}