{"doi":"10.17615/e0ab-1y15","title":"Structure and evolution of the human IKBA gene","abstract":"IκBα belongs to a gene family whose members are characterized by their 6-7 Ankyrin repeats, which allow them to interact with members of the Rel family of transcription factors. We have sequenced a human IκBα genomic clone to determine its gene structure. The human IκBα gene (IKBA) has six exons and five introns that span approximately 3.5 kb. This genomic organization is similar to that of other members of the Ankyrin gene family. The humanIKBAgene shares similar intron/exon boundaries with the humanBCL3andNFKB2genes, which is consistent with their conserved Ankyrin repeats. To examine further the evolutionary relationship between human IκBα and other members of its gene family, we performed a phylogenetic analysis. Although the resulting phylogenetic tree does not identify a common ancestor of the IκBα gene family, it indicates that this family diverges into two groups based on structure and function.","journal":"UNC Libraries","year":2022,"id":304483,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9228,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":997897,"name":"N. Adey","orcid":null,"position":1,"is_corresponding":false},{"id":450372,"name":"A.S. Baldwin","orcid":null,"position":2,"is_corresponding":false},{"id":997898,"name":"C.Y. Ito","orcid":null,"position":3,"is_corresponding":false},{"id":997896,"name":"V.L. Bautch","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:32:32.651796Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}