{"doi":"10.17615/d6vp-s897","title":"Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis","abstract":"Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.","journal":"UNC Libraries","year":2020,"id":112931,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":533449,"name":"Xuming Dai","orcid":"0000-0003-3092-9323","position":1,"is_corresponding":false},{"id":534241,"name":"Joseph Stavas","orcid":null,"position":2,"is_corresponding":false},{"id":292645,"name":"Paul A. Dayton","orcid":"0000-0002-5757-6911","position":3,"is_corresponding":false},{"id":533450,"name":"Wei-Yi Chang","orcid":"0000-0003-1000-8121","position":4,"is_corresponding":false},{"id":374255,"name":"Brooks D. Lindsey","orcid":"0000-0001-7128-108X","position":5,"is_corresponding":false},{"id":325196,"name":"Xiaoning Jiang","orcid":"0000-0003-3605-3801","position":6,"is_corresponding":false},{"id":348380,"name":"Jinwook Kim","orcid":"0000-0002-2072-3922","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:17.845093Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}