{"doi":"10.17615/d2kz-az38","title":"SARS-CoV-2 infection among people living with HIV compared with people without HIV: Survey results from the MACS-WIHS combined cohort study","abstract":"Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) symptoms among people living with HIV (PLWH) are not well described. Setting: Longitudinal survey within the MACS/WIHS Combined Cohort Study (MWCCS) of PLWH compared with similar HIVseronegative (SN) individuals. Methods: Telephone-administered survey of MWCCS participants at 13 clinical research sites across the United States addressing COVID-19 symptoms, SARS-CoV-2 testing, and pandemic impact on social distancing and antiretroviral therapy (ART) use. Primary data collection occurred during May (wave 1), June-July (wave 2), and August-September, 2020 (wave 3). Results: One-third of MWCCS participants were tested for SARSCoV- 2 infection; 10% was tested ≥2 times. Similar proportions of PLWH and SN participants were tested, but SARS-CoV-2 positivity was higher among PLWH than among SN individuals (9.4% vs 4.8%, P = 0.003). Odds of SARS-CoV-2 positivity remained higher among PLWH after adjusting for age, sex, race/ethnicity, and study site (adjusted odds ratio = 2.0, 95% confidence interval = 1.2 to 3.2). SARS-CoV-2 positivity was not associated with CD4 cell counts among PLWH. Among SARS-CoV-2 positive participants, 9% had no symptoms, 7% had 1-2 mild symptoms, and 84% had ≥3 symptoms. Most of the (98%) participants reported physical distancing during all survey waves; self-reported ART adherence among PLWH was not adversely affected during the pandemic compared with the previous year (similar adherence in 89% of participants, improved in 9% of participants, and decreased in 2% of participants). Conclusions: Despite similar SARS-CoV-2 testing and physical distancing profiles by HIV serostatus among MWCCS participants, PLWH who reported SARS-CoV-2 testing were more likely to have a positive test result. Additional studies are needed to determine whether and why PLWH are at increased risk of SARS-CoV-2 infection.","journal":"UNC Libraries","year":2023,"id":415818,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6066,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1198285,"name":"C.R. Rinaldo","orcid":null,"position":1,"is_corresponding":false},{"id":596998,"name":"M.-C. Kempf","orcid":null,"position":2,"is_corresponding":false},{"id":690554,"name":"Cecile D. Lahiri","orcid":"0000-0002-5605-8266","position":3,"is_corresponding":false},{"id":1197926,"name":"Carlos Ramírez","orcid":"0000-0001-6558-595X","position":4,"is_corresponding":false},{"id":591356,"name":"A.A. Adimora","orcid":null,"position":5,"is_corresponding":false},{"id":591352,"name":"P.C. Tien","orcid":null,"position":6,"is_corresponding":false},{"id":954938,"name":"Winnie Tong","orcid":"0000-0003-2235-8452","position":7,"is_corresponding":false},{"id":1159138,"name":"A. Sharma","orcid":"0009-0001-4508-3984","position":8,"is_corresponding":false},{"id":596997,"name":"S. Kassaye","orcid":null,"position":9,"is_corresponding":false},{"id":1198276,"name":"A.L. French","orcid":null,"position":10,"is_corresponding":false},{"id":597004,"name":"D. Gustafson","orcid":null,"position":11,"is_corresponding":false},{"id":270178,"name":"Matthew J. Mimiaga","orcid":"0000-0001-9256-2905","position":12,"is_corresponding":false},{"id":591316,"name":"F.J. Palella","orcid":null,"position":13,"is_corresponding":false},{"id":409544,"name":"María L. Alcaide","orcid":"0000-0003-4648-0145","position":14,"is_corresponding":false},{"id":1198286,"name":"T.T. Brown","orcid":null,"position":15,"is_corresponding":false},{"id":1198284,"name":"G. D’Souza","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:22:15.958504Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}