{"doi":"10.17615/cv5f-1047","title":"Pretherapy metabolic tumor volume is associated with response to CD30 CAR T cells in Hodgkin lymphoma","abstract":"Our group has recently demonstrated that chimeric antigen receptor T-cell therapy targeting the CD30 antigen (CD30.CAR-T) is highly effective in patients with relapsed and refractory (r/r) classical Hodgkin lymphoma (cHL). Despite high rates of clinical response, relapses and progression were observed in a subset of patients. The objective of this study was to characterize clinical and correlative factors associated with progression-free survival (PFS) after CD30.CAR-T cell therapy. We evaluated correlatives in 27 patients with r/r cHL treated with lymphodepletion and CD30.CAR-T cells. With a median follow-up of 9.5 months, 17 patients (63%) progressed, with a median PFS of 352 days (95% confidence interval: 116-not reached), and 2 patients died (7%) with a median overall survival of not reached. High metabolic tumor volume (MTV, .60 mL) immediately before lymphodepletion and CD30.CAR-T cell infusion was associated with inferior PFS (log rank, P 5 .02), which persisted after adjusting for lymphodepletion and CAR-T dose (log rank, P 5 .01 and P 5 .006, respectively). In contrast, receiving bridging therapy, response to bridging therapy, CD30.CAR-T expansion/persistence, and percentage of CD31PD-11 lymphocytes over the first 6 weeks of therapy were not associated with differences in PFS. In summary, this study reports an association between high baseline MTV immediately before lymphodepletion and CD30.CAR-T cell infusion and worse PFS in patients with r/r cHL.","journal":"UNC Libraries","year":2024,"id":499090,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":771149,"name":"B. Savoldo","orcid":null,"position":1,"is_corresponding":false},{"id":1346928,"name":"Chien-Jui Cheng","orcid":null,"position":2,"is_corresponding":false},{"id":666038,"name":"George Hucks","orcid":"0000-0002-4515-7277","position":3,"is_corresponding":false},{"id":835173,"name":"A.W. Beaven","orcid":null,"position":4,"is_corresponding":false},{"id":667081,"name":"J. Kaitlin Morrison","orcid":null,"position":5,"is_corresponding":false},{"id":835170,"name":"T.J. Voorhees","orcid":null,"position":6,"is_corresponding":false},{"id":1346929,"name":"Chris Dittus","orcid":null,"position":7,"is_corresponding":false},{"id":835174,"name":"N. Grover","orcid":null,"position":8,"is_corresponding":false},{"id":389600,"name":"Thomas C. Shea","orcid":null,"position":9,"is_corresponding":false},{"id":36210,"name":"Bo Zhao","orcid":"0000-0001-7188-5959","position":10,"is_corresponding":false},{"id":396585,"name":"A. Ivanova","orcid":null,"position":11,"is_corresponding":false},{"id":538085,"name":"Amir H. Khandani","orcid":"0000-0003-3629-5472","position":12,"is_corresponding":false},{"id":835172,"name":"J. Serody","orcid":null,"position":13,"is_corresponding":false},{"id":1346143,"name":"Sophie Park","orcid":"0000-0003-0514-5789","position":14,"is_corresponding":false},{"id":666037,"name":"Jorge D. Oldan","orcid":"0000-0002-8979-2010","position":15,"is_corresponding":false},{"id":1346144,"name":"J. E. Smith","orcid":"0000-0002-2206-3534","position":16,"is_corresponding":false},{"id":744177,"name":"G. Dotti","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}