{"doi":"10.17615/cdyx-qb49","title":"B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study","abstract":"Introduction: Particulate air pollutants may induce neurotoxicity by increasing homocysteine levels, which can be lowered by high B vitamin intakes. Therefore, we examined whether intakes of three B vitamins (folate, B12, and B6) modified the association between PM2.5 exposure and incidence of all-cause dementia. Methods: This study included 7183 women aged 65 to 80 years at baseline. B vitamin intakes from diet and supplements were estimated by food frequency questionnaires at baseline. The 3-year average PM2.5 exposure was estimated using a spatiotemporal model. Results: During a mean follow-up of 9 years, 342 participants developed all-cause dementia. We found that residing in locations with PM2.5 exposure above the regulatory standard (12 μg/m3) was associated with a higher risk of dementia only among participants with lower intakes of these B vitamins. Discussion: This is the first study suggesting that the putative neurotoxicity of PM2.5 exposure may be attenuated by high B vitamin intakes.","journal":"UNC Libraries","year":2024,"id":499495,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9252,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":176671,"name":"J Chen","orcid":null,"position":1,"is_corresponding":false},{"id":226606,"name":"Mark A. Espeland","orcid":"0000-0002-3711-1949","position":2,"is_corresponding":false},{"id":1347440,"name":"X. Wang","orcid":"0000-0002-8779-4514","position":3,"is_corresponding":false},{"id":266060,"name":"Joel D. Kaufman","orcid":"0000-0003-4174-9037","position":4,"is_corresponding":false},{"id":1347441,"name":"Helena Chui","orcid":"0000-0001-5567-9282","position":5,"is_corresponding":false},{"id":117863,"name":"C Chen","orcid":null,"position":6,"is_corresponding":false},{"id":393535,"name":"Mary E. D’Alton","orcid":"0000-0002-1457-6284","position":7,"is_corresponding":false},{"id":243123,"name":"Linda Snetselaar","orcid":"0000-0002-6615-0779","position":8,"is_corresponding":false},{"id":279446,"name":"William Vizuete","orcid":"0000-0002-1399-2948","position":9,"is_corresponding":false},{"id":547600,"name":"Archana P. Lamichhane","orcid":null,"position":10,"is_corresponding":false},{"id":835152,"name":"M.L Serre","orcid":null,"position":11,"is_corresponding":false},{"id":258460,"name":"Kathleen M. Hayden","orcid":"0000-0002-7745-3513","position":12,"is_corresponding":false},{"id":218550,"name":"Eric A. Whitsel","orcid":"0000-0003-4843-3641","position":13,"is_corresponding":false},{"id":435657,"name":"Ka Kahe","orcid":"0000-0001-5078-2010","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:53.188165Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}