{"doi":"10.17615/cbqf-q844","title":"TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination","abstract":"Sex-determining genes have been identified in many animals, but how they impose sex specificity on development is poorly understood. We ask how the nematode sex-determining transcription factor Transformer 1 (TRA-1) regulates sex by identifying where in the genome TRA-1 binds and which nearby genes may be affected by this binding. We find that TRA-1 promotes female development primarily by preventing the expression of genes involved in male development. Among the genes repressed by TRA-1 are a number that control the timing of developmental events and also several that function upstream of TRA-1 in the global sex-determination pathway. The suite of TRA-1 targets presented here provides a resource to continue uncovering the basis of sex-specific development.","journal":"UNC Libraries","year":2020,"id":116368,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":545049,"name":"D. Zarkower","orcid":null,"position":1,"is_corresponding":false},{"id":349099,"name":"K. Ikegami","orcid":null,"position":2,"is_corresponding":false},{"id":545050,"name":"S. Arur","orcid":null,"position":3,"is_corresponding":false},{"id":545051,"name":"M. Berkseth","orcid":null,"position":4,"is_corresponding":false},{"id":393735,"name":"J. D. Lieb","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:44.286758Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}