{"doi":"10.17615/bxh8-g735","title":"Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation","abstract":"Basal-like breast cancers (BLBCs) are aggressive, and their drivers are unclear. We have found that wild-type N-RAS is overexpressed in BLBCs but not in other breast cancer subtypes. Repressing N-RAS inhibits transformation and tumor growth, whereas overexpression enhances these processes even in preinvasive BLBC cells. We identified N-Ras-responsive genes, most of which encode chemokines; e.g., IL8. Expression levels of these chemokines and N-RAS in tumors correlate with outcome. N-Ras, but not K-Ras, induces IL-8 by binding and activating the cytoplasmic pool of JAK2; IL-8 then acts on both the cancer cells and stromal fibroblasts. Thus, BLBC progression is promoted by increasing activities of wild-type N-Ras, which mediates autocrine/paracrine signaling that can influence both cancer and stroma cells.","journal":"UNC Libraries","year":2021,"id":210846,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":799744,"name":"Yi‐Hua Liao","orcid":"0000-0002-4434-3780","position":1,"is_corresponding":false},{"id":327184,"name":"Xiang Zhang","orcid":"0000-0003-1003-9892","position":2,"is_corresponding":false},{"id":13376,"name":"Chad J. Creighton","orcid":"0000-0002-6090-703X","position":3,"is_corresponding":false},{"id":376163,"name":"Yi Li","orcid":"0000-0002-9976-518X","position":4,"is_corresponding":false},{"id":361212,"name":"Eric L. Chang","orcid":"0000-0003-2708-6724","position":5,"is_corresponding":false},{"id":799745,"name":"Michael Lewis","orcid":"0000-0001-5933-8557","position":6,"is_corresponding":false},{"id":799746,"name":"Daniel Medina","orcid":"0000-0001-9421-949X","position":7,"is_corresponding":false},{"id":506755,"name":"Xia Gao","orcid":"0000-0002-4539-5929","position":8,"is_corresponding":false},{"id":800380,"name":"Zheng, Ze-Yi","orcid":null,"position":9,"is_corresponding":false},{"id":800381,"name":"Dean Edwards","orcid":null,"position":10,"is_corresponding":false},{"id":44715,"name":"Susan G. Hilsenbeck","orcid":"0000-0002-7962-673X","position":11,"is_corresponding":false},{"id":1883,"name":"Charles M. Perou","orcid":"0000-0001-9827-2247","position":12,"is_corresponding":false},{"id":2418,"name":"Thomas P. Zwaka","orcid":"0000-0002-9271-2456","position":13,"is_corresponding":false},{"id":404355,"name":"Wen Bu","orcid":"0000-0002-9939-9407","position":14,"is_corresponding":false},{"id":381829,"name":"Cheng Fan","orcid":"0000-0002-3471-6221","position":15,"is_corresponding":false},{"id":799747,"name":"Lin Tian","orcid":"0000-0002-6889-2178","position":16,"is_corresponding":false},{"id":267160,"name":"Hai Wang","orcid":"0000-0002-6999-554X","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:52:16.049481Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}