{"doi":"10.17615/bvr4-z939","title":"Pubertal and adult windows of susceptibility to a high animal fat diet in Trp53-null mammary tumorigenesis","abstract":"Premenopausal breast cancer is associated with increased animal fat consumption among normal weight, but not overweight women (Farvid et al., 2014). Our previous findings in obesity-resistant BALB/c mice similarly showed promotion of carcinogen-induced mammary tumorigenesis by a diet high in saturated animal fat (HFD). This effect was specific to pubertal versus adult HFD. This study identifies the effects of HFD during puberty versus adulthood in Trp53-null transplant BALB/c mice and investigates its mechanism of enhancing tumorigenesis. Either pubertal or adult HFD is sufficient to increase incidence of Trp53-null mammary tumors. Puberty-restricted HFD exposure promoted tumor cell proliferation, increased angiogenesis, and increased recruitment of total and M2 macrophages in epithelial tumors. Adult-restricted exposure to HFD similarly increased proliferation, angiogenesis, recruitment of total and M2 macrophages, and additionally reduced apoptosis. Adult HFD also increased incidence of spindle cell carcinomas resembling claudin-low breast cancer, and thus adult HFD in the Trp53-null transplantation system may be a useful model for human claudin low breast cancer. Importantly, these results on Trp53-null and our prior studies on DMBA-induced mammary tumorigenesis demonstrate a pubertal window of susceptibility to the promotional effects of HFD, indicating the potential of early life dietary intervention to reduce breast cancer risk.","journal":"UNC Libraries","year":2020,"id":111533,"datarank":0.2770041316216342,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.008240211237425922,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.008240211237425922,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":4,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":529706,"name":"E.L. Kirk","orcid":null,"position":1,"is_corresponding":false},{"id":528946,"name":"Ying Tan","orcid":"0000-0003-2634-7347","position":2,"is_corresponding":false},{"id":499050,"name":"Yong Zhao","orcid":"0000-0001-5068-2212","position":3,"is_corresponding":false},{"id":507713,"name":"Sandra Z. Haslam","orcid":null,"position":4,"is_corresponding":false},{"id":507714,"name":"Richard C. Schwartz","orcid":null,"position":5,"is_corresponding":false},{"id":507711,"name":"Mark D. Aupperlee","orcid":null,"position":6,"is_corresponding":false},{"id":453989,"name":"Xuezheng Sun","orcid":null,"position":7,"is_corresponding":false},{"id":529707,"name":"Zhu, Yirong","orcid":null,"position":8,"is_corresponding":false},{"id":270126,"name":"Melissa A. Troester","orcid":"0000-0001-9506-6624","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:13:05.597252Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}