{"doi":"10.17615/bhpk-5y17","title":"MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11","abstract":"Chemotherapy resistance frequently drives tumour progression. However, the underlying molecular mechanisms are poorly characterized. Epithelial-to-mesenchymal transition (EMT) has been shown to correlate with therapy resistance, but the functional link and signalling pathways remain to be elucidated. We report here that miR-30c, a human breast tumour prognostic marker, plays a pivotal role in chemo-resistance by a direct targeting of TWF1, which encodes an actin-binding protein and promotes EMT. An IL-6 family member, IL-11 was identified as a secondary target of TWF1 in the miR-30c signalling pathway. Expression of miR-30c inversely correlated with TWF1 and IL-11 levels in primary breast tumours and low IL-11 correlated with relapse-free survival in breast cancer patients. Our study demonstrates that miR-30c is transcriptionally regulated by GATA3 in breast tumours. Identification of a novel miRNA-mediated pathway that regulates chemo-resistance in breast cancer will facilitate the development of novel therapeutic strategies.","journal":"UNC Libraries","year":2020,"id":144545,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":315670,"name":"Geoffrey L. Greene","orcid":"0000-0001-6894-8728","position":1,"is_corresponding":false},{"id":1883,"name":"Charles M. Perou","orcid":"0000-0001-9827-2247","position":2,"is_corresponding":false},{"id":556230,"name":"Yujia Wen","orcid":"0009-0000-5398-4494","position":3,"is_corresponding":false},{"id":612989,"name":"Seo Young Park","orcid":"0000-0002-2702-1536","position":4,"is_corresponding":false},{"id":613635,"name":"Ya-Fang Chang","orcid":null,"position":5,"is_corresponding":false},{"id":612990,"name":"Jun Lu","orcid":"0000-0003-0225-6643","position":6,"is_corresponding":false},{"id":6442,"name":"Olufunmilayo I. Olopade","orcid":"0000-0002-9936-1599","position":7,"is_corresponding":false},{"id":415422,"name":"Dezheng Huo","orcid":"0000-0002-4041-1678","position":8,"is_corresponding":false},{"id":601518,"name":"Kaitlin E. Swanson","orcid":null,"position":9,"is_corresponding":false},{"id":601516,"name":"Kathy Yee","orcid":null,"position":10,"is_corresponding":false},{"id":613636,"name":"Tyler Qiu","orcid":null,"position":11,"is_corresponding":false},{"id":600944,"name":"Simo Huang","orcid":"0000-0003-3318-0143","position":12,"is_corresponding":false},{"id":297924,"name":"Huiping Liu","orcid":"0000-0003-4822-7995","position":13,"is_corresponding":false},{"id":600945,"name":"Michael F. Clarke","orcid":"0000-0003-1138-2908","position":14,"is_corresponding":false},{"id":424513,"name":"M. Eileen Dolan","orcid":"0000-0003-1613-097X","position":15,"is_corresponding":false},{"id":259626,"name":"Aleix Prat","orcid":"0000-0003-2377-540X","position":16,"is_corresponding":false},{"id":328840,"name":"Rachel Dalton","orcid":"0000-0001-8902-1155","position":17,"is_corresponding":false},{"id":601515,"name":"Jessica Bockhorn","orcid":null,"position":18,"is_corresponding":false},{"id":235194,"name":"Chika Nwachukwu","orcid":"0000-0001-9732-9352","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:45.339291Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}