{"doi":"10.17615/bcda-sh71","title":"K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif","abstract":"The KRAS oncogene is mutated more frequently in human cancer than any other. The KRAS transcript is alternatively spliced to give rise to two products, K-Ras4A and K-Ras4B, both of which are oncogenic when KRAS is mutated. We detected significant amounts of each transcript in human tumor cells and colorectal carcinomas. We found that K-Ras4A is targeted to the plasma membrane by dual targeting motifs distinct from those of K-Ras4B. Because interfering with membrane association of Ras proteins remains one of the most attractive approaches to anti-Ras therapy, efforts in this direction will have to disrupt both the K-Ras4A and the K-Ras4B membrane-targeting pathways.","journal":"UNC Libraries","year":2020,"id":136609,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":595032,"name":"Frederick D. Tsai","orcid":"0000-0001-8497-5064","position":1,"is_corresponding":false},{"id":449324,"name":"Adrienne D. Cox","orcid":"0000-0002-4901-2454","position":2,"is_corresponding":false},{"id":595033,"name":"Mo Zhou","orcid":"0000-0003-3538-7666","position":3,"is_corresponding":false},{"id":595764,"name":"Helen Court","orcid":null,"position":4,"is_corresponding":false},{"id":251203,"name":"Mark R. Philips","orcid":"0000-0002-1179-8156","position":5,"is_corresponding":false},{"id":595765,"name":"Odis Ponce","orcid":null,"position":6,"is_corresponding":false},{"id":595034,"name":"Mathew S. Lopes","orcid":"0000-0003-0092-8194","position":7,"is_corresponding":false},{"id":450310,"name":"James J. Fiordalisi","orcid":null,"position":8,"is_corresponding":false},{"id":337818,"name":"Kevin M. Haigis","orcid":"0000-0003-1922-4509","position":9,"is_corresponding":false},{"id":595763,"name":"Jessica J. Gierut","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:48.793683Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}