{"doi":"10.17615/b066-4975","title":"SARS-CoV-2 Testing and Positivity among Persons with and Without HIV in 6 US Cohorts","abstract":"Background:It is not definitively known if persons with HIV (PWH) are more likely to be SARS-CoV-2 tested or test positive than persons without HIV (PWoH). We describe SARS-CoV-2 testing and positivity in 6 large geographically and demographically diverse cohorts of PWH and PWoH in the United States.Setting:The Corona Infectious Virus Epidemiology Team comprises 5 clinical cohorts within a health system (Kaiser Permanente Northern California, Oakland, CA; Kaiser Permanente Mid-Atlantic States, Rockville, MD; University of North Carolina Health, Chapel Hill, NC; Vanderbilt University Medical Center, Nashville, TN; and Veterans Aging Cohort Study) and 1 interval cohort (Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort Study).Methods:We calculated the proportion of patients SARS-CoV-2 tested and the test positivity proportion by HIV status from March 1 to December 31, 2020.Results:The cohorts ranged in size from 1675 to 31,304 PWH and 1430 to 3,742,604 PWoH. The proportion of PWH who were tested for SARS-CoV-2 (19.6%-40.5% across sites) was significantly higher than PWoH (14.8%-29.4%) in the clinical cohorts. However, among those tested, the proportion of patients with positive SARS-CoV-2 tests was comparable by HIV status; the difference in proportion of SARS-CoV-2 positivity ranged from 4.7% lower to 1.4% higher.Conclusions:Although PWH had higher testing proportions compared with PWoH, we did not find evidence of increased positivity in 6 large, diverse populations across the United States. Ongoing monitoring of testing, positivity, and COVID-19-related outcomes in PWH are needed, given availability, response, and durability of COVID-19 vaccines; emergence of SARS-CoV-2 variants; and latest therapeutic options.","journal":"UNC Libraries","year":2023,"id":410738,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5366,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":636517,"name":"Jacek Skarbinski","orcid":"0000-0003-1630-5733","position":1,"is_corresponding":false},{"id":421195,"name":"Wendy A. Leyden","orcid":null,"position":2,"is_corresponding":false},{"id":557883,"name":"Carolyn Williams","orcid":"0000-0002-5667-486X","position":3,"is_corresponding":false},{"id":31022,"name":"Lisa Bastarache","orcid":null,"position":4,"is_corresponding":false},{"id":551050,"name":"K.N. Althoff","orcid":null,"position":5,"is_corresponding":false},{"id":1190974,"name":"L. Benning","orcid":null,"position":6,"is_corresponding":false},{"id":449210,"name":"Lesley S. Park","orcid":"0000-0002-3848-7753","position":7,"is_corresponding":false},{"id":474122,"name":"J.K. Edwards","orcid":null,"position":8,"is_corresponding":false},{"id":806309,"name":"Julia M. Certa","orcid":"0000-0002-0176-5019","position":9,"is_corresponding":false},{"id":1190975,"name":"C. Jefferson","orcid":null,"position":10,"is_corresponding":false},{"id":591340,"name":"A.C. Justice","orcid":null,"position":11,"is_corresponding":false},{"id":591329,"name":"M.J. Silverberg","orcid":null,"position":12,"is_corresponding":false},{"id":207368,"name":"Kathleen A. McGinnis","orcid":null,"position":13,"is_corresponding":false},{"id":1190976,"name":"S. Gangireddy","orcid":null,"position":14,"is_corresponding":false},{"id":474120,"name":"D. Westreich","orcid":null,"position":15,"is_corresponding":false},{"id":315093,"name":"Gypsyamber DʼSouza","orcid":"0000-0002-0575-7948","position":16,"is_corresponding":false},{"id":340146,"name":"Sonia Napravnik","orcid":"0000-0002-9032-3713","position":17,"is_corresponding":false},{"id":240247,"name":"Michael A. Horberg","orcid":"0000-0002-6971-7646","position":18,"is_corresponding":false},{"id":431790,"name":"Kirsha S. Gordon","orcid":"0000-0002-4925-1914","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:21:35.071397Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}