{"doi":"10.17615/aycf-t384","title":"Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults","abstract":"Interleukin-6 (IL-6) is an inflammatory cytokine that influences the development of inflammatory and aging-related disorders and ultimately longevity. In order to study the influence of variants in genes that regulate inflammatory response on IL-6 levels and longevity, we screened a panel of 477 tag SNPs across 87 candidate genes in >5,000 older participants from the population-based Cardiovascular Health Study (CHS). Baseline plasma IL-6 concentration was first confirmed as a strong predictor of all-cause mortality. Functional alleles of the IL6R and PARP1 genes were significantly associated with 15%-20% higher baseline IL-6 concentration per copy among CHS European-American (EA) participants (all p<10−4). In a case/control analysis nested within this EA cohort, the minor allele of PARP1 rs1805415 was nominally associated with decreased longevity (p=0.001), but there was no evidence of association between IL6R genotype and longevity. The PARP1 rs1805415 – longevity association was subsequently replicated in one of two independent case/control studies. In a pooled analysis of all 3 studies, the “risk” of longevity associated with the minor allele of PARP1 rs1805415 was 0.79 (95%CI 0.62 – 1.02; p=0.07). These findings warrant further study of the potential role of PARP1 genotype in inflammatory and aging-related phenotypes.","journal":"UNC Libraries","year":2020,"id":144588,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9146,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":302270,"name":"Andrea Z. LaCroix","orcid":"0000-0002-9532-976X","position":1,"is_corresponding":false},{"id":94249,"name":"Pui–Yan Kwok","orcid":"0000-0002-5087-3059","position":2,"is_corresponding":false},{"id":613693,"name":"Amy M. Matteini","orcid":null,"position":3,"is_corresponding":false},{"id":90076,"name":"Nir Barzilai","orcid":"0000-0002-7787-6268","position":4,"is_corresponding":false},{"id":1031,"name":"Gil Atzmon","orcid":"0000-0001-6895-3607","position":5,"is_corresponding":false},{"id":11363,"name":"Charles Kooperberg","orcid":"0000-0002-7986-8560","position":6,"is_corresponding":false},{"id":613694,"name":"Dani Fallin","orcid":null,"position":7,"is_corresponding":false},{"id":613019,"name":"Ludmila Pawlikowska","orcid":"0000-0003-2182-9953","position":8,"is_corresponding":false},{"id":11309,"name":"Ethan M. Lange","orcid":"0000-0001-7075-4287","position":9,"is_corresponding":false},{"id":24984,"name":"Leslie A. Lange","orcid":"0000-0002-4220-6766","position":10,"is_corresponding":false},{"id":52036,"name":"Elad Ziv","orcid":"0000-0002-2324-2884","position":11,"is_corresponding":false},{"id":25028,"name":"Russell P. Tracy","orcid":"0000-0002-0080-2420","position":12,"is_corresponding":false},{"id":576667,"name":"Steve Cummings","orcid":null,"position":13,"is_corresponding":false},{"id":25010,"name":"Alex P. Reiner","orcid":"0000-0002-1427-4470","position":14,"is_corresponding":false},{"id":57359,"name":"Jeremy Walston","orcid":"0000-0002-6965-2723","position":15,"is_corresponding":false},{"id":35454,"name":"Caroline M. Nievergelt","orcid":"0000-0001-5766-8923","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:45.339291Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}