{"doi":"10.17615/aagn-qc46","title":"Antiretroviral Therapy Initiated During Acute HIV Infection Fails to Prevent Persistent T-Cell Activation","abstract":"Initiation of ART during acute HIV-1 infection may prevent persistent immune activation. We analyzed longitudinal CD38+HLA-DR+ CD8+ T cell percentages in 31 acutely infected individuals who started early (median 43 days since infection) and successful ART, and maintained viral suppression through 96 weeks. Pre-therapy a median of 72.6% CD8+ T cells were CD38+HLA-DR+, and while this decreased to 15.6% by 96 weeks, it remained substantially higher than seronegative controls (median 8.9%, p=0.008). Shorter time to suppression predicted lower activation at 96 weeks. These results support the hypothesis that very early events in HIV-1 pathogenesis may result in prolonged immune dysfunction.","journal":"UNC Libraries","year":2020,"id":141545,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340103,"name":"Anna B. Cope","orcid":"0000-0001-7599-196X","position":1,"is_corresponding":false},{"id":249714,"name":"Guido Ferrari","orcid":"0000-0001-7747-3349","position":2,"is_corresponding":false},{"id":309905,"name":"JoAnn D. Kuruc","orcid":null,"position":3,"is_corresponding":false},{"id":524565,"name":"Charles B. Hicks","orcid":null,"position":4,"is_corresponding":false},{"id":105520,"name":"David M. Margolis","orcid":"0000-0001-5714-0002","position":5,"is_corresponding":false},{"id":249715,"name":"Cynthia L. Gay","orcid":"0000-0002-3620-3059","position":6,"is_corresponding":false},{"id":592345,"name":"Kara McGee","orcid":"0000-0003-1560-8820","position":7,"is_corresponding":false},{"id":393581,"name":"Michael J. Vinikoor","orcid":"0000-0002-3862-7795","position":8,"is_corresponding":false},{"id":428567,"name":"Jeffrey L. Lennox","orcid":"0000-0002-2064-5565","position":9,"is_corresponding":false},{"id":249713,"name":"Joseph J. Eron","orcid":"0000-0002-4938-0644","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:24.429854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}