{"doi":"10.17615/a9qw-d013","title":"Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction","abstract":"Objective: To determine whether walking speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR), is associated with inter-extremity differences in proteoglycan density, measured via T1ρ magnetic resonance imaging, in tibiofemoral articular cartilage 12 months following ACLR. Methods: Twenty-one individuals with a unilateral patellar-tendon autograft ACLR (10 women and 11 men, mean ± SD age 23.9 ± 2.7 years, mean ± SD body mass index 23.9 ± 2.7 kg/m2) were recruited for participation in this study. Walking speed was collected using 3-dimensional motion capture at 6 and 12 months following ACLR. The articular cartilage of the medial femoral condyle (MFC) and lateral femoral condyle and medial and lateral tibial condyles was manually segmented and subsectioned into 3 regions of interest (anterior, central, and posterior) based on the location of the meniscus in the sagittal plane. Inter-extremity mean T1ρ relaxation time ratios (T1ρ ACLR extremity / T1ρ contralateral extremity) were calculated and used for analysis. Pearson product-moment correlations were used to determine associations between walking speed and inter-extremity differences in T1ρ relaxation time ratios. Results: Slower walking speed 6 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the MFC of the ACLR extremity 12 months following ACLR (posterior MFC, r = −0.51, P = 0.02; central MFC, r = −0.47, P = 0.04). Similarly, slower walking speed at 12 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the posterior MFC ACLR extremity (r = −0.47, P = 0.04) 12 months following ACLR. Conclusion: Slower walking speed at 6 and 12 months following ACLR may be associated with early proteoglycan density changes in medial femoral compartment cartilage health in the first 12 months following ACLR.","journal":"UNC Libraries","year":2024,"id":498974,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9075,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":434129,"name":"Randy J. Schmitz","orcid":"0000-0001-6599-2299","position":1,"is_corresponding":false},{"id":1223431,"name":"S. Pfeiffer","orcid":null,"position":2,"is_corresponding":false},{"id":406180,"name":"Matthew S. Harkey","orcid":"0000-0002-3480-3173","position":3,"is_corresponding":false},{"id":338352,"name":"J. Troy Blackburn","orcid":null,"position":4,"is_corresponding":false},{"id":1345981,"name":"L.E. Stanley","orcid":"0000-0002-5355-6454","position":5,"is_corresponding":false},{"id":318561,"name":"Joanne M. Jordan","orcid":"0000-0003-2469-9955","position":6,"is_corresponding":false},{"id":336909,"name":"Darin A. Padua","orcid":"0000-0002-9383-4236","position":7,"is_corresponding":false},{"id":1157125,"name":"D. Nissman","orcid":null,"position":8,"is_corresponding":false},{"id":336911,"name":"Brian Pietrosimone","orcid":"0000-0002-2632-413X","position":9,"is_corresponding":false},{"id":374581,"name":"Jeffrey T. Spang","orcid":"0000-0003-3610-7339","position":10,"is_corresponding":false},{"id":338712,"name":"Stephen W. Marshall","orcid":"0000-0002-2664-9233","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}