{"doi":"10.17615/a7c7-d723","title":"L-Selectin Is Dispensable for T Regulatory Cell Function Postallogeneic Bone Marrow Transplantation: CD62L−/− Tregs Inhibit Acute GvHD","abstract":"In murine models, the adoptive transfer of CD4+/CD25+ regulatory T cells (Tregs) inhibited graft-versus-host disease (GvHD). Previous work has indicated a critical role for the adhesion molecule L-selectin (CD62L) in the function of Tregs in preventing GvHD. Here we examined the capacity of naive wild-type (WT), CD62L−/− and ex vivo expanded CD62LLo Tregs to inhibit acute GvHD. Surprisingly, we found that CD62L−/− Tregs were potent suppressors of GvHD, whereas CD62LLo Tregs were unable to inhibit disease despite being functionally competent to suppress allo T cell responses in vitro. Concomitant with improved outcomes, WT and CD62L−/− Tregs significantly reduced liver pathology and systemic pro-inflammatory cytokine production, although CD62L−/− Tregs were less effective in reducing lung pathology. While accumulation of CD62L−/− Tregs in GvHD target organs was equivalent to WT Tregs, CD62L−/− Tregs did not migrate as well as WT Tregs to peripheral lymph nodes (PLNs) over the first 2 weeks posttransplantation. This work demonstrated that CD62L was dispensable for Treg-mediated protection from GvHD.","journal":"UNC Libraries","year":2020,"id":135856,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":488197,"name":"Angela Panoskaltsis‐Mortari","orcid":"0000-0003-1802-1785","position":1,"is_corresponding":false},{"id":593376,"name":"Lynette Fulton","orcid":"0000-0002-9640-5840","position":2,"is_corresponding":false},{"id":594099,"name":"J. M. Coghill","orcid":null,"position":3,"is_corresponding":false},{"id":538644,"name":"B. R. Blazar","orcid":null,"position":4,"is_corresponding":false},{"id":538646,"name":"J. S. Serody","orcid":null,"position":5,"is_corresponding":false},{"id":440706,"name":"T. F. Tedder","orcid":null,"position":6,"is_corresponding":false},{"id":594100,"name":"M. L. West","orcid":null,"position":7,"is_corresponding":false},{"id":594101,"name":"Y. Wan","orcid":null,"position":8,"is_corresponding":false},{"id":594102,"name":"M. J. Carlson","orcid":null,"position":9,"is_corresponding":false},{"id":594098,"name":"J. E. Burgents","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:16:35.237665Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}