{"doi":"10.17615/a5w5-ha78","title":"Role of Reactive Oxygen Species in Hyperadrenergic Hypertension: Biochemical, Physiological, and Pharmacological Evidence From Targeted Ablation of the Chromogranin A (Chga) Gene","abstract":"Oxidative stress, an excessive production of reactive oxygen species (ROS) outstripping antioxidant defense mechanisms, occurs in cardiovascular pathologies including hypertension. Here, we used biochemical, physiological, and pharmacological approaches to explore the role of derangements of catecholamines, ROS, and NO• in the development of a hyper-adrenergic model of hereditary hypertension: targeted ablation (knockout, KO) of chromogranin A (Chga) in the mouse.","journal":"UNC Libraries","year":2020,"id":117690,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":548992,"name":"Kuixing Zhang","orcid":null,"position":1,"is_corresponding":false},{"id":548361,"name":"Yuqing Chen","orcid":"0000-0003-3430-4451","position":2,"is_corresponding":false},{"id":264428,"name":"Robert K. Naviaux","orcid":"0000-0001-5832-2297","position":3,"is_corresponding":false},{"id":548362,"name":"Sushil K. Mahata","orcid":"0000-0002-8300-9873","position":4,"is_corresponding":false},{"id":548993,"name":"Daniel T. O’Connor","orcid":null,"position":5,"is_corresponding":false},{"id":548363,"name":"Satish P. RamachandraRao","orcid":"0000-0002-0680-7994","position":6,"is_corresponding":false},{"id":539356,"name":"Jiaur R. Gayen","orcid":"0000-0001-7703-9307","position":7,"is_corresponding":false},{"id":548994,"name":"Manjula Mahata","orcid":null,"position":8,"is_corresponding":false},{"id":292969,"name":"Kumar Sharma","orcid":"0000-0002-7550-8525","position":9,"is_corresponding":false},{"id":548360,"name":"Hyung‐Suk Kim","orcid":"0000-0001-5939-2211","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:54.951170Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}