{"doi":"10.17615/a5p2-9p02","title":"Acute Pulmonary Function Response to Ozone in Young Adults As a Function of Body Mass Index","abstract":"Recent studies have shown enhanced responsiveness to ozone in obese mice. Adiposity has not been examined as a possible modulator of ozone response in humans. We therefore examined the relationship between body mass index and the acute spirometric response to ozone (O3) exposure among 197 non-asthmatic young adults (aged 18-35) studied in our human exposure facility from 1992-1998. Each subject had been exposed to 0.42 ppm O3 for 1.5 h with intermittent exercise designed to produce a minute ventilation of 20 l/min / m2 body surface area (BSA). Spirometry (pulmonary function) was measured pre- and immediately post- exposure to determine acute ozone-induced changes. The decrement in forced expiratory volume in 1s (Δ FEV1) in % of baseline was significantly correlated with BMI, r = −0.16, p = 0.03 with a slightly stronger correlation in women (n=75), r = −0.22, p = 0.05, and no significant correlation in men. BMI had a greater range in women than in men in our study. In women greater ozone-induced decrements were seen in overweight (BMI > 25 kg/m2) than in normal weight (BMI 18.5 to 25 kg/m2), and in normal weight than in underweight (BMI < 18.5 kg/m2) for all spirometric variables considered (P trend ≤ 0.022). Although our population studied was predominantly normal weight, we found that higher body mass index may be a modest risk factor for adverse pulmonary effects associated with ozone exposure, especially for women.","journal":"UNC Libraries","year":2020,"id":144577,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":532788,"name":"Grace E. Kissling","orcid":null,"position":1,"is_corresponding":false},{"id":613665,"name":"Lawrence J. Folinsbee","orcid":null,"position":2,"is_corresponding":false},{"id":512721,"name":"Milan J. Hazucha","orcid":null,"position":3,"is_corresponding":false},{"id":284286,"name":"William D. Bennett","orcid":"0000-0002-6054-0768","position":4,"is_corresponding":false},{"id":5170,"name":"Stephanie J. London","orcid":"0000-0003-4911-5290","position":5,"is_corresponding":false},{"id":544011,"name":"Philip A. Bromberg","orcid":"0000-0002-7431-6652","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:45.339291Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}