{"doi":"10.17615/9xe6-zy34","title":"Translational studies of phenotypic probes for the mononuclear phagocyte system and liposomal pharmacologys","abstract":"As nanoparticles (NPs) are cleared via phagocytes of the mononuclear phagocyte system (MPS), we hypothesized that the function of circulating monocytes and dendritic cells (MO/DC) in blood can predict NP clearance (CL). We measured MO/DC phagocytosis and reactive oxygen species (ROS) production in mice, rats, dogs, and patients with refractory solid tumors. Pharmacokinetic studies of polyethylene glycol (PEG)-encapsulated liposomal doxorubicin (PEGylated liposomal doxirubicin [PLD]), CKD-602 (S-CKD602), and cisplatin (SPI-077) were performed at the maximum tolerated dose. MO/DC function was also evaluated in patients with recurrent epithelial ovarian cancer (EOC) administered PLD. Across species, a positive association was observed between cell function and CL of PEGylated liposomes. In patients with EOC, associations were observed between PLD CL and phagocytosis (R2 = 0.43, P = 0.04) and ROS production (R2 = 0.61, P = 0.008) in blood MO/DC. These findings suggest that probes of MPS function may help predict PEGylated liposome CL across species and PLD CL in patients with EOC.","journal":"UNC Libraries","year":2020,"id":142044,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9692,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":608602,"name":"N. M. La-Beck","orcid":null,"position":1,"is_corresponding":false},{"id":608603,"name":"S. E. Newman","orcid":null,"position":2,"is_corresponding":false},{"id":538482,"name":"L. Van Le","orcid":null,"position":3,"is_corresponding":false},{"id":608604,"name":"J. C. Lay","orcid":null,"position":4,"is_corresponding":false},{"id":543606,"name":"W. C. Zamboni","orcid":null,"position":5,"is_corresponding":false},{"id":608605,"name":"P. A. Gehrig","orcid":null,"position":6,"is_corresponding":false},{"id":608606,"name":"J. H. Monaco","orcid":null,"position":7,"is_corresponding":false},{"id":43910,"name":"P. Kumar","orcid":"0000-0001-5523-4603","position":8,"is_corresponding":false},{"id":608607,"name":"W. R. Brewster","orcid":null,"position":9,"is_corresponding":false},{"id":608608,"name":"W. P. Caron","orcid":null,"position":10,"is_corresponding":false},{"id":608609,"name":"V. L. Bae-Jump","orcid":null,"position":11,"is_corresponding":false},{"id":27191,"name":"H. Zhou","orcid":"0000-0002-7986-9045","position":12,"is_corresponding":false},{"id":608610,"name":"A. M. Fong","orcid":null,"position":13,"is_corresponding":false},{"id":608601,"name":"D. Clarke-Pearson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:27.861239Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}