{"doi":"10.17615/96z6-2e27","title":"Assessing Clinical Relevance of Uremic Toxins","abstract":"Standard hemodialysis works. Indeed, this procedure maintains life in hundreds of thousands of people with little or no kidney function. Moreover, severe symptoms of uremia—coma, seizures, acidosis, hyperkalemia, and pulmonary edema—are readily reversed by dialysis. However, it is also now conspicuous that life on maintenance hemodialysis is short, with about 20%of the ESKDpopulation in the United States dying each year, yielding a 3–5years survival rate of only 50%. Although mortality is appallingly high, patient symptom burden is great, and for many patients, these symptoms are more daunting than the dismal mortality prospects. Quality of life has remained consistently poor for patients on hemodialysis. A recent survey reported that the physical symptoms of insomnia, fatigue, andcramping, andmoodsymptoms of anxiety, depression, and frustration were paramount concerns among patients","journal":"UNC Libraries","year":2024,"id":501461,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":241192,"name":"Jennifer E. Flythe","orcid":"0000-0003-4596-8536","position":1,"is_corresponding":false},{"id":444905,"name":"Thomas H. Hostetter","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:15.999370Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}