{"doi":"10.17615/8mwc-2x45","title":"The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy","abstract":"The mitochondrial protein MAVS (also known as IPS-1, VISA, CARDIF) interacts with RLR (RIG-I-like receptors) to induce type 1 interferon (IFN-I) during viral infection. NLRX1 is a mitochondrial NLR (nucleotide-binding, leucine-rich repeats containing) protein that attenuates MAVS-RLR signaling. Using Nlrx1−/− cells we confirmed NLRX1 attenuated IFN-I production, but additionally promoted autophagy during viral infection. This dual function of NLRX1 paralleled the previously described functions of the autophagy-related proteins Atg5-Atg12, but NLRX1 did not associate with Atg5-Atg12. High throughput quantitative mass spectrometry and endogenous protein-protein interaction revealed an NLRX1-interacting partner, mitochondrial Tu translation elongation factor (TUFM). TUFM interacted with Atg5-Atg12 and Atg16L1, and has similar functions as NLRX1 by inhibiting RLR-induced IFN-I but promoting autophagy. In the absence of NLRX1, increased IFN-I and decreased autophagy provide an advantage for host defense against vesicular stomatitis virus. This study establishes a link between an NLR protein and the viral-induced autophagic machinery via an intermediary partner, TUFM.","journal":"UNC Libraries","year":2020,"id":140724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":540993,"name":"Xian Chen","orcid":"0000-0002-0731-8930","position":1,"is_corresponding":false},{"id":392045,"name":"Lei Yu","orcid":"0000-0003-1093-9188","position":2,"is_corresponding":false},{"id":263811,"name":"Blossom Damania","orcid":"0000-0002-9205-1774","position":3,"is_corresponding":false},{"id":522208,"name":"Lu Zhang","orcid":"0000-0001-9049-8807","position":4,"is_corresponding":false},{"id":241767,"name":"Babak Razani","orcid":"0000-0002-7172-9240","position":5,"is_corresponding":false},{"id":437994,"name":"David P. Siderovski","orcid":"0000-0002-0688-8210","position":6,"is_corresponding":false},{"id":392046,"name":"Haitao Wen","orcid":"0000-0002-6375-4171","position":7,"is_corresponding":false},{"id":435879,"name":"Douglas G. Widman","orcid":"0000-0002-3585-6373","position":8,"is_corresponding":false},{"id":522211,"name":"Karen V. Swanson","orcid":"0000-0003-3105-0599","position":9,"is_corresponding":false},{"id":548260,"name":"Patrick M. Giguère","orcid":"0000-0002-7520-8290","position":10,"is_corresponding":false},{"id":11782,"name":"Yanbao Yu","orcid":"0000-0003-2994-1974","position":11,"is_corresponding":false},{"id":605547,"name":"John Hiscott","orcid":"0000-0003-2076-6321","position":12,"is_corresponding":false},{"id":502184,"name":"Debra J. Taxman","orcid":null,"position":13,"is_corresponding":false},{"id":225654,"name":"Jenny P.‐Y. Ting","orcid":"0000-0002-3282-419X","position":14,"is_corresponding":false},{"id":599740,"name":"Chris B. Moore","orcid":"0000-0003-0957-0440","position":15,"is_corresponding":false},{"id":606055,"name":"Kwun-Wah Wen","orcid":null,"position":16,"is_corresponding":false},{"id":241850,"name":"Clay F. Semenkovich","orcid":"0000-0003-1163-1871","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:17:20.701143Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}