{"doi":"10.17615/8cfb-kp75","title":"Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study","abstract":"We previously demonstrated an association between lipoprotein (a) [Lp(a)] levels and atherosclerosis in human immunodeficiency virus (HIV)-seropositive women. The effects of antiretroviral therapy (ART) on Lp(a) levels in relation to apo(a) size polymorphism remain unclear. ART effects on allele-specific apo(a) level (ASL), an Lp(a) level associated with individual apo(a) alleles within each allele-pair, were determined in 126 HIV-seropositive women. ART effects were tested by a mixed-effects model across pre-ART and post-ART first and third visits. Data from 120 HIV-seronegative women were used. The mean age was 38 years; most were African-American (∼70%). Pre-ART ASLs associated with the larger (4.6 mg/dl vs. 8.0 mg/dl, P = 0.024) or smaller (13 mg/dl vs. 19 mg/dl, P = 0.041) apo(a) sizes were lower in the HIV-seropositive versus HIV-seronegative group, as was the prevalence of a high Lp(a) level (P = 0.013). Post-ART ASL and prevalence of high Lp(a) or apo(a) sizes and frequency of small size apo(a) (≤22 kringles) did not differ between the two groups. ART increased Lp(a) level (from 18 to 24 mg/dl, P < 0.0001) and both ASLs (P < 0.001). In conclusion, regardless of genetic control, Lp(a) can be modulated by HIV and its treatment. ART initiation abrogates HIV-induced suppression of Lp(a) levels and ASLs, contributing to promote CVD risk in HIV-seropositive individuals.","journal":"UNC Libraries","year":2023,"id":415861,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":597016,"name":"B. Aouizerat","orcid":null,"position":1,"is_corresponding":false},{"id":295814,"name":"Savita Pahwa","orcid":"0000-0002-4470-4216","position":2,"is_corresponding":false},{"id":591356,"name":"A.A. Adimora","orcid":null,"position":3,"is_corresponding":false},{"id":1198251,"name":"C.-S. Li","orcid":null,"position":4,"is_corresponding":false},{"id":597006,"name":"I. Ofotokun","orcid":null,"position":5,"is_corresponding":false},{"id":1198250,"name":"E. Anuurad","orcid":null,"position":6,"is_corresponding":false},{"id":597014,"name":"E. Golub","orcid":null,"position":7,"is_corresponding":false},{"id":440310,"name":"Robert C. Kaplan","orcid":"0000-0003-3271-801X","position":8,"is_corresponding":false},{"id":1198249,"name":"J. Lazar","orcid":null,"position":9,"is_corresponding":false},{"id":515169,"name":"Weihe Zhang","orcid":"0000-0003-2923-9130","position":10,"is_corresponding":false},{"id":442449,"name":"Lars Berglund","orcid":"0000-0001-6705-1791","position":11,"is_corresponding":false},{"id":249130,"name":"Daniel Merenstein","orcid":"0000-0002-8808-6907","position":12,"is_corresponding":false},{"id":442444,"name":"Byambaa Enkhmaa","orcid":"0000-0002-1429-6864","position":13,"is_corresponding":false},{"id":437151,"name":"M. Cohen","orcid":null,"position":14,"is_corresponding":false},{"id":1198248,"name":"R. Karim","orcid":null,"position":15,"is_corresponding":false},{"id":534999,"name":"Kenneth R. Butler","orcid":"0000-0003-3198-8835","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:22:15.958504Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}