{"doi":"10.17615/7y5d-7972","title":"Effects of Antiretroviral Therapy and Depressive Symptoms on All-Cause Mortality Among HIV-Infected Women","abstract":"Abstract Depression affects up to 30% of human immunodeficiency virus (HIV)-infected individuals. We estimated joint effects of antiretroviral therapy (ART) initiation and depressive symptoms on time to death using a joint marginal structural model and data from a cohort of HIV-infected women from the Women's Interagency HIV Study (conducted in the United States) from 1998–2011. Among 848 women contributing 6,721 years of follow-up, 194 participants died during follow-up, resulting in a crude mortality rate of 2.9 per 100 women-years. Cumulative mortality curves indicated greatest mortality for women who reported depressive symptoms and had not initiated ART. The hazard ratio for depressive symptoms was 3.38 (95% confidence interval (CI): 2.15, 5.33) and for ART was 0.47 (95% CI: 0.31, 0.70). Using a reference category of women without depressive symptoms who had initiated ART, the hazard ratio for women with depressive symptoms who had initiated ART was 3.60 (95% CI: 2.02, 6.43). For women without depressive symptoms who had not started ART, the hazard ratio was 2.36 (95% CI: 1.16, 4.81). Among women reporting depressive symptoms who had not started ART, the hazard ratio was 7.47 (95% CI: 3.91, 14.3). We found a protective effect of ART initiation on mortality, as well as a harmful effect of depressive symptoms, in a cohort of HIV-infected women.","journal":"UNC Libraries","year":2020,"id":139690,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9065,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":6027,"name":"Brian W. Pence","orcid":"0000-0001-7321-9538","position":1,"is_corresponding":false},{"id":603251,"name":"Cuiwei Wang","orcid":"0000-0002-0712-7739","position":2,"is_corresponding":false},{"id":239681,"name":"Peter Bacchetti","orcid":"0000-0002-9323-2972","position":3,"is_corresponding":false},{"id":520810,"name":"Аnna Rubtsova","orcid":"0000-0002-0573-0980","position":4,"is_corresponding":false},{"id":311288,"name":"Daniel J. Feaster","orcid":"0000-0002-6172-7460","position":5,"is_corresponding":false},{"id":240246,"name":"Stephen J. Gange","orcid":"0000-0001-7842-512X","position":6,"is_corresponding":false},{"id":301953,"name":"Adaora A. Adimora","orcid":"0000-0001-5035-1552","position":7,"is_corresponding":false},{"id":329434,"name":"Mardge H. Cohen","orcid":"0000-0002-1351-9624","position":8,"is_corresponding":false},{"id":75349,"name":"Wendy J. Mack","orcid":"0000-0002-2474-7921","position":9,"is_corresponding":false},{"id":329432,"name":"Stephen R. Cole","orcid":"0000-0003-2117-1311","position":10,"is_corresponding":false},{"id":603252,"name":"Jonathan Todd","orcid":"0000-0001-6396-2379","position":11,"is_corresponding":false},{"id":211067,"name":"Kathryn Anastos","orcid":"0000-0002-0769-6405","position":12,"is_corresponding":false},{"id":603768,"name":"Jeremy Weedon","orcid":null,"position":13,"is_corresponding":false},{"id":272406,"name":"Catherine R. Lesko","orcid":"0000-0002-1717-2592","position":14,"is_corresponding":false},{"id":90099,"name":"Michael Griswold","orcid":"0000-0001-8106-5516","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:13.583586Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}