{"doi":"10.17615/7mj8-9t66","title":"Admixture mapping identifies an amerindian ancestry locus associated with albuminuria in hispanics in the United States","abstract":"Increased urine albumin excretion is highly prevalent in Hispanics/Latinos. Previous studies have found an association between urine albumin excretion and Amerindian ancestry in Hispanic/Latino populations. Admixture between racial/ ethnic groups creates long-range linkage disequilibrium between variants with different allelic frequencies in the founding populations and it can be used to localize genes. Hispanic/Latino genomes are an admixture of European, African, and Amerindian ancestries. We leveraged this admixture to identify associations between urine albumin excretion (urine albumin-to-creatinine ratio [UACR]) and genomic regions harboring variants with highly differentiated allele frequenciesamongtheancestralpopulations.Admixturemappinganalysis of 12,212HispanicCommunityHealth Study/Study of Latinos participants, using a linearmixedmodel, identified three novel genome-wide significant signals on chromosomes 2, 11, and 16. The admixture mapping signal identified on chromosome2, spanning q11.2-14.1 and notpreviously reported forUACR,isdrivenby a differencebetween Amerindian ancestry and theother twoancestries (P<5.7 × 10-5). Within this locus, two common variants located at the proapoptotic BCL2L11 gene associated with UACR: rs116907128 (allele frequency=0.14;P=1.531027) and rs586283 (Callele frequency=0.35;P=4.2×10-7). In a secondary analysis, rs116907128 accounted for most of the admixture mapping signal observed in the region. The rs116907128 variant is commonamong full-heritage Pima Indians (A allele frequency=0.54) but ismonomorphic in the 1000Genomes European and African populations. In a replication analysis using a sample of full-heritage Pima Indians, rs116907128 significantly associated with UACR (P=0.01; n=1568).Our findingsprovideevidence for thepresenceof Amerindian-specific variants influencing the variation of urine albumin excretion in Hispanics/Latinos.","journal":"UNC Libraries","year":2024,"id":499019,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":980420,"name":"C.C. Laurie","orcid":null,"position":1,"is_corresponding":false},{"id":24792,"name":"Holly Kramer","orcid":"0000-0002-6374-837X","position":2,"is_corresponding":false},{"id":277166,"name":"James P. Lash","orcid":"0000-0002-6580-4080","position":3,"is_corresponding":false},{"id":57755,"name":"T. Sofer","orcid":null,"position":4,"is_corresponding":false},{"id":245900,"name":"Sharon R. Browning","orcid":"0000-0001-7251-9715","position":5,"is_corresponding":false},{"id":17008,"name":"Susan Redline","orcid":"0000-0002-6585-1610","position":6,"is_corresponding":false},{"id":38114,"name":"Daniel Levy","orcid":"0000-0003-1843-8724","position":7,"is_corresponding":false},{"id":1314684,"name":"A.M. Stilp","orcid":null,"position":8,"is_corresponding":false},{"id":577698,"name":"Jianwen Cai","orcid":"0000-0003-1813-0594","position":9,"is_corresponding":false},{"id":1346771,"name":"Ivica Mašindová","orcid":null,"position":10,"is_corresponding":false},{"id":439829,"name":"Leslie J. Baier","orcid":"0000-0002-8773-9670","position":11,"is_corresponding":false},{"id":1346060,"name":"Lisa Brown","orcid":"0000-0002-3794-9549","position":12,"is_corresponding":false},{"id":231212,"name":"Sylvia E. Rosas","orcid":"0000-0002-9903-4002","position":13,"is_corresponding":false},{"id":529783,"name":"N. Franceschini","orcid":null,"position":14,"is_corresponding":false},{"id":1346061,"name":"Tim Thornton","orcid":"0000-0002-0137-1554","position":15,"is_corresponding":false},{"id":836525,"name":"R.L. Hanson","orcid":null,"position":16,"is_corresponding":false},{"id":835797,"name":"A.E. Moncrieft","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:09:45.971055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}