{"doi":"10.17615/73h8-rx33","title":"Test-retest and between-site reliability in a multicenter fMRI study","abstract":"In the present report, estimates of test–retest and between-site reliability of fMRI assessments were produced in the context of a multicenter fMRI reliability study (FBIRN Phase 1, www.nbirn.net). Five subjects were scanned on 10 MRI scanners on two occasions. The fMRI task was a simple block design sensorimotor task. The impulse response functions to the stimulation block were derived using an FIR-deconvolution analysis with FMRISTAT. Six functionally-derived ROIs covering the visual, auditory and motor cortices, created from a prior analysis, were used. Two dependent variables were compared: percent signal change and contrast-to-noise-ratio. Reliability was assessed with intraclass correlation coefficients derived from a variance components analysis. Test–retest reliability was high, but initially, between-site reliability was low, indicating a strong contribution from site and site-by-subject variance. However, a number of factors that can markedly improve between-site reliability were uncovered, including increasing the size of the ROIs, adjusting for smoothness differences, and inclusion of additional runs. By employing multiple steps, between-site reliability for 3T scanners was increased by 123%. Dropping one site at a time and assessing reliability can be a useful method of assessing the sensitivity of the results to particular sites. These findings should provide guidance to others on the best practices for future multicenter studies.","journal":"UNC Libraries","year":2020,"id":143595,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7388,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":603422,"name":"William A. Wells","orcid":"0000-0003-4360-1263","position":1,"is_corresponding":false},{"id":235047,"name":"Bryon A. Mueller","orcid":"0000-0003-2429-0391","position":2,"is_corresponding":false},{"id":226064,"name":"Steven G. Potkin","orcid":"0000-0003-1028-1013","position":3,"is_corresponding":false},{"id":611171,"name":"Padhraic Smyth","orcid":"0000-0001-9971-8378","position":4,"is_corresponding":false},{"id":611782,"name":"Jianchun He","orcid":null,"position":5,"is_corresponding":false},{"id":289038,"name":"Randy L. Gollub","orcid":"0000-0002-9434-4044","position":6,"is_corresponding":false},{"id":24074,"name":"Seyoung Kim","orcid":"0000-0002-0408-1165","position":7,"is_corresponding":false},{"id":342687,"name":"Douglas N. Greve","orcid":"0000-0002-0610-0155","position":8,"is_corresponding":false},{"id":14565,"name":"Steve Pieper","orcid":"0000-0003-4193-9578","position":9,"is_corresponding":false},{"id":611783,"name":"H. Jeremy Bockholt","orcid":null,"position":10,"is_corresponding":false},{"id":126643,"name":"John Lauriello","orcid":null,"position":11,"is_corresponding":false},{"id":611172,"name":"Lee S. Friedman","orcid":"0000-0001-9312-6099","position":12,"is_corresponding":false},{"id":90656,"name":"Jessica A. Turner","orcid":"0000-0003-0076-8434","position":13,"is_corresponding":false},{"id":32595,"name":"Gary H. Glover","orcid":"0000-0002-0562-0474","position":14,"is_corresponding":false},{"id":302333,"name":"Márk Vangel","orcid":"0000-0003-2993-2365","position":15,"is_corresponding":false},{"id":463696,"name":"Hal S. Stern","orcid":"0000-0002-5657-2820","position":16,"is_corresponding":false},{"id":611784,"name":"Michael J. Doty","orcid":null,"position":17,"is_corresponding":false},{"id":523634,"name":"Ayşenil Belger","orcid":"0000-0003-2687-1966","position":18,"is_corresponding":false},{"id":411598,"name":"Tyrone D. Cannon","orcid":"0000-0002-5632-3154","position":19,"is_corresponding":false},{"id":513377,"name":"Gregory G. Brown","orcid":"0000-0002-6430-9854","position":20,"is_corresponding":false},{"id":398316,"name":"Marek Kubicki","orcid":"0000-0002-3989-8212","position":21,"is_corresponding":false},{"id":289811,"name":"Daniel H. Mathalon","orcid":"0000-0001-6090-4974","position":22,"is_corresponding":false},{"id":331553,"name":"Kelvin O. Lim","orcid":"0000-0002-2390-7268","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:38.432803Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}