{"doi":"10.17615/6fhs-9w52","title":"IL-11 antagonist suppresses Th17 cell-mediated neuroinflammation and demyelination in a mouse model of relapsing-remitting multiple sclerosis","abstract":"IL-11 induced differentiation and expansion of Th17 cells in patients with early relapsing-remitting multiple sclerosis (RRMS). In mice with relapsing-remitting experimental autoimmune encephalomyelitis (RREAE), IL-11 exacerbated disease, induced demyelination in the central nervous system (CNS), increased the percentage of IL-17A+CD4+ Th17 cells in the CNS in the early acute phase, and up-regulated serum IL-17A levels and the percentage of IL-17A+CD4+ Th17 cells in lymph nodes, and IFN-γ+CD4+ T cells in spinal cord in the RR phase. IL-11 antagonist suppressed RREAE disease activities, inhibited IL-17A+CD4+ cell infiltration and demyelination in the CNS, and decreased the percentage of IL-17A+CD4+ T cells in peripheral blood mononuclear cells and ICAM1+CD4+ T cells in brain and SC. Diffusion Tensor Imaging indicated that IL-11 antagonist inhibited demyelination in several brain regions. We conclude that by suppressing Th17 cell-mediated neuroinflammation and demyelination, IL-11 antagonist can be further studied as a potential selective and early therapy for RRMS.","journal":"UNC Libraries","year":2024,"id":501495,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":593618,"name":"Bentley R. Midkiff","orcid":"0000-0002-6565-9055","position":1,"is_corresponding":false},{"id":271355,"name":"Yen‐Yu Ian Shih","orcid":"0000-0001-6529-911X","position":2,"is_corresponding":false},{"id":333833,"name":"Stephanie M. Cohen","orcid":"0000-0003-4784-5548","position":3,"is_corresponding":false},{"id":732855,"name":"Nazanin Kiapour","orcid":"0000-0002-7473-415X","position":4,"is_corresponding":false},{"id":593313,"name":"Silva Markovic‐Plese","orcid":"0000-0002-0061-2707","position":5,"is_corresponding":false},{"id":732854,"name":"Sahil Kapoor","orcid":"0000-0003-3553-382X","position":6,"is_corresponding":false},{"id":318935,"name":"Woomi Ban","orcid":null,"position":7,"is_corresponding":false},{"id":611874,"name":"Joseph R. Merrill","orcid":"0000-0003-3680-1988","position":8,"is_corresponding":false},{"id":590664,"name":"Valerie Jewells","orcid":"0000-0002-2844-3263","position":9,"is_corresponding":false},{"id":1351197,"name":"Yongjuan Xia","orcid":null,"position":10,"is_corresponding":false},{"id":253460,"name":"Xin Zhang","orcid":"0000-0001-7390-4439","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:15.999370Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}