{"doi":"10.17615/63y3-pk15","title":"Aurora-A Kinase Is Essential for Bipolar Spindle Formation and Early Development","abstract":"Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. Aurora-A was previously implicated in mitotic entry and spindle assembly, although contradictory results prevented a clear understanding of the roles of Aurora-A in mammals. We developed a conditional null mutation in the mouse Aurora-A gene to investigate Aurora-A functions in primary cells ex vivo and in vivo. We show here that conditional Aurora-A ablation in cultured embryonic fibroblasts causes impaired mitotic entry and mitotic arrest with a profound defect in bipolar spindle formation. Germ line Aurora-A deficiency causes embryonic death at the blastocyst stage with pronounced cell proliferation failure, mitotic arrest, and monopolar spindle formation. Aurora-A deletion in mid-gestation embryos causes an increase in mitotic and apoptotic cells. These results indicate that murine Aurora-A facilitates, but is not absolutely required for, mitotic entry in murine embryonic fibroblasts and is essential for centrosome separation and bipolar spindle formation in vitro and in vivo. Aurora-A deletion increases apoptosis, suggesting that molecular therapies targeting Aurora-A may be effective in inducing tumor cell apoptosis. Aurora-A conditional mutant mice provide a valuable system for further defining Aurora-A functions and for predicting effects of Aurora-A therapeutic intervention.","journal":"UNC Libraries","year":2020,"id":110232,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":526028,"name":"R. O'Quinn","orcid":null,"position":1,"is_corresponding":false},{"id":41387,"name":"L. Lu","orcid":"0000-0003-3175-7770","position":2,"is_corresponding":false},{"id":526029,"name":"T. G. Oliver","orcid":null,"position":3,"is_corresponding":false},{"id":526030,"name":"T. Van Dyke","orcid":null,"position":4,"is_corresponding":false},{"id":526031,"name":"T. Magnuson","orcid":null,"position":5,"is_corresponding":false},{"id":438838,"name":"E. D. Salmon","orcid":null,"position":6,"is_corresponding":false},{"id":526032,"name":"J. A. Rivera-Perez","orcid":null,"position":7,"is_corresponding":false},{"id":526033,"name":"M. Schliekelman","orcid":null,"position":8,"is_corresponding":false},{"id":522157,"name":"Y. J. He","orcid":"0009-0009-8511-0850","position":9,"is_corresponding":false},{"id":526027,"name":"D. O. Cowley","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:12:57.988348Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}