{"doi":"10.17615/5zd1-c995","title":"Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter?","abstract":"Background: Promoting catch-up growth in malnourished children has health benefits, but recent evidence suggests that accelerated child weight gain increases adult chronic disease risk.Objective: We aimed to determine how birth weight (BW) and weight gain to midchildhood relate to blood pressure (BP) in young adults.Design: We pooled data from birth cohorts in Brazil, Guatemala, India, the Philippines, and South Africa. We used conditional weight (CW), a residual of current weight regressed on prior weights, to represent deviations from expected weight gain from 0 to 12, 12 to 24, 24 to 48 mo, and 48 mo to adulthood. Adult BP and risk of prehypertension or hypertension (P/HTN) were modeled before and after adjustment for adult body mass index (BMI) and height. Interactions of CWs with small size-for-gestational age (SGA) at birth were tested.Results: Higher CWs were associated with increased BP and odds of P/HTN, with coefficients proportional to the contribution of each CW to adult BMI. Adjusted for adult height and BMI, no child CW was associated with adult BP, but 1 SD of BW was related to a 0.5-mm Hg lower systolic BP and a 9% lower odds of P/HTN. BW and CW associations with systolic BP and P/HTN were not different between adults born SGA and those with normal BW, but higher CW at 48 mo was associated with higher diastolic BP in those born SGA.Conclusions: Greater weight gain at any age relates to elevated adult BP, but faster weight gains in infancy and young childhood do not pose a higher risk than do gains at other ages.","journal":"UNC Libraries","year":2020,"id":139448,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":438375,"name":"Sang Lee","orcid":"0000-0001-9701-2718","position":1,"is_corresponding":false},{"id":38911,"name":"Reynaldo Martorell","orcid":"0000-0001-8862-7243","position":2,"is_corresponding":false},{"id":298901,"name":"Shane A. Norris","orcid":"0000-0001-7124-3788","position":3,"is_corresponding":false},{"id":23230,"name":"Dorairaj Prabhakaran","orcid":"0000-0002-3172-834X","position":4,"is_corresponding":false},{"id":39596,"name":"César G. Victora","orcid":"0000-0002-2465-2180","position":5,"is_corresponding":false},{"id":602884,"name":"Pedro C. Hallal","orcid":null,"position":6,"is_corresponding":false},{"id":324211,"name":"Linda S. Adair","orcid":"0000-0002-3670-8073","position":7,"is_corresponding":false},{"id":39556,"name":"Harshpal Singh Sachdev","orcid":"0000-0002-4956-9391","position":8,"is_corresponding":false},{"id":39202,"name":"Aryeh D. Stein","orcid":"0000-0003-1138-6458","position":9,"is_corresponding":false},{"id":602885,"name":"Darren L. Dahly","orcid":null,"position":10,"is_corresponding":false},{"id":434344,"name":"Andrew K. Wills","orcid":"0000-0002-9751-4707","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:10.185988Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}