{"doi":"10.17615/5kw4-n671","title":"Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration","abstract":"AbstractCyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory drugs. To study the physiological roles of the individual isoforms, we have disrupted the mouse Ptgs1 gene encoding COX-1. Homozygous Ptgs1 mutant mice survive well, have no gastric pathology, and show less indomethacin-induced gastric ulceration than wild-type mice, even though their gastric prostaglandin E2 levels are about 1% of wild type. The homozygous mutant mice have reduced platelet aggregation and a decreased inflammatory response to arachidonic acid, but not to tetradecanoyl phorbol acetate. Ptgs1 homozygous mutant females mated to homozygous mutant males produce few live offspring. COX-1-deficient mice provide a useful model to distinguish the physiological roles of COX-1 and COX-2.","journal":"UNC Libraries","year":2021,"id":231100,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":838302,"name":"Patricia C. Chulada","orcid":null,"position":1,"is_corresponding":false},{"id":144154,"name":"H.S. Kim","orcid":null,"position":2,"is_corresponding":false},{"id":592605,"name":"Kimberly D. Kluckman","orcid":null,"position":3,"is_corresponding":false},{"id":838027,"name":"Christopher A. Lee","orcid":"0000-0001-7988-0394","position":4,"is_corresponding":false},{"id":362882,"name":"Eugenia H. Goulding","orcid":null,"position":5,"is_corresponding":false},{"id":838303,"name":"Charles D. Loftin","orcid":null,"position":6,"is_corresponding":false},{"id":427441,"name":"Burhan I. Ghanayem","orcid":null,"position":7,"is_corresponding":false},{"id":838304,"name":"Joel F. Mahler","orcid":null,"position":8,"is_corresponding":false},{"id":45210,"name":"Oliver Smithies","orcid":"0000-0002-4934-3931","position":9,"is_corresponding":false},{"id":202717,"name":"Howard F. Tiano","orcid":null,"position":10,"is_corresponding":false},{"id":612127,"name":"Robert Langenbach","orcid":null,"position":11,"is_corresponding":false},{"id":601610,"name":"Scott G. Morham","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:55:12.400773Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}