{"doi":"10.17615/5k1p-eh22","title":"Potent and broad HIV-neutralizing antibodies in memory B cells and plasma","abstract":"Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. Antibody 10E8, reactive with the distal portion of the membrane-proximal external region (MPER) of HIV-1 gp41, is broadly neutralizing. However, the ontogeny of distal MPER antibodies and the relationship of memory B cell to plasma bnAbs are poorly understood. HIV-1–specific memory B cell flow sorting and proteomic identification of anti-MPER plasma antibodies from an HIV-1–infected individual were used to isolate broadly neutralizing distal MPER bnAbs of the same B cell clonal lineage. Structural analysis demonstrated that antibodies from memory B cells and plasma recognized the envelope gp41 bnAb epitope in a distinct orientation compared with other distal MPER bnAbs. The unmutated common ancestor of this distal MPER bnAb was autoreactive, suggesting lineage immune tolerance control. Construction of chimeric antibodies of memory B cell and plasma antibodies yielded a bnAb that potently neutralized most HIV-1 strains.","journal":"UNC Libraries","year":2023,"id":415760,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1111223,"name":"Guojun Yang","orcid":null,"position":1,"is_corresponding":false},{"id":836791,"name":"T.B. Kepler","orcid":null,"position":2,"is_corresponding":false},{"id":1198142,"name":"G.D. Tomaras","orcid":null,"position":3,"is_corresponding":false},{"id":594816,"name":"Robin J. Parks","orcid":"0000-0002-4959-2233","position":4,"is_corresponding":false},{"id":597931,"name":"M.S. Cohen","orcid":null,"position":5,"is_corresponding":false},{"id":1198159,"name":"Sebastian Schätzle","orcid":null,"position":6,"is_corresponding":false},{"id":105614,"name":"John R. Mascola","orcid":"0000-0002-5293-4695","position":7,"is_corresponding":false},{"id":603774,"name":"Dawn J. Marshall","orcid":null,"position":8,"is_corresponding":false},{"id":327283,"name":"D. C. Montefiori","orcid":null,"position":9,"is_corresponding":false},{"id":292261,"name":"Hua‐Xin Liao","orcid":"0000-0002-7871-1334","position":10,"is_corresponding":false},{"id":541513,"name":"S.-M. Xia","orcid":null,"position":11,"is_corresponding":false},{"id":548908,"name":"T. Bradley","orcid":null,"position":12,"is_corresponding":false},{"id":1197891,"name":"Karen L. McKee","orcid":"0000-0001-7042-670X","position":13,"is_corresponding":false},{"id":392854,"name":"Jonathan R. McDaniel","orcid":"0000-0001-8575-3535","position":14,"is_corresponding":false},{"id":106348,"name":"George Georgiou","orcid":"0000-0002-8823-3073","position":15,"is_corresponding":false},{"id":1011146,"name":"K.O. Saunders","orcid":null,"position":16,"is_corresponding":false},{"id":268925,"name":"Kshitij Wagh","orcid":"0000-0001-7552-6582","position":17,"is_corresponding":false},{"id":329634,"name":"Laurel Morris","orcid":"0000-0002-5862-6650","position":18,"is_corresponding":false},{"id":437158,"name":"G. Kamanga","orcid":null,"position":19,"is_corresponding":false},{"id":1197892,"name":"Xiaoyan Nie","orcid":"0000-0002-1443-2176","position":20,"is_corresponding":false},{"id":258350,"name":"S. Munir Alam","orcid":"0000-0003-0941-0703","position":21,"is_corresponding":false},{"id":437154,"name":"N.L. Tumba","orcid":null,"position":22,"is_corresponding":false},{"id":1198160,"name":"R. T. Bailer","orcid":null,"position":23,"is_corresponding":false},{"id":290894,"name":"Ivelin S. Georgiev","orcid":"0000-0002-6312-7696","position":24,"is_corresponding":false},{"id":601089,"name":"Kara Anasti","orcid":"0000-0002-1854-743X","position":25,"is_corresponding":false},{"id":218078,"name":"Sijy O’Dell","orcid":"0000-0002-4951-8471","position":26,"is_corresponding":false},{"id":1198161,"name":"C.S. Lougheed","orcid":null,"position":27,"is_corresponding":false},{"id":1198162,"name":"M.S. Seaman","orcid":null,"position":28,"is_corresponding":false},{"id":590896,"name":"M.K. Louder","orcid":null,"position":29,"is_corresponding":false},{"id":105515,"name":"Nathan I. Nicely","orcid":"0000-0002-0025-2377","position":30,"is_corresponding":false},{"id":280566,"name":"Garnett Kelsoe","orcid":"0000-0002-8770-040X","position":31,"is_corresponding":false},{"id":1198163,"name":"L.D. Williams","orcid":null,"position":32,"is_corresponding":false},{"id":438040,"name":"Feng Gao","orcid":"0000-0002-9563-3841","position":33,"is_corresponding":false},{"id":548907,"name":"B.F. Haynes","orcid":null,"position":34,"is_corresponding":false},{"id":1198164,"name":"M. Bonsignori","orcid":null,"position":35,"is_corresponding":false},{"id":1198165,"name":"K. Wiehe","orcid":null,"position":36,"is_corresponding":false},{"id":1197893,"name":"Xin Lu","orcid":"0000-0002-1684-4465","position":37,"is_corresponding":false},{"id":1198155,"name":"M.A. Moody","orcid":null,"position":38,"is_corresponding":false},{"id":302764,"name":"Lan Wu","orcid":"0000-0002-1966-2501","position":39,"is_corresponding":false},{"id":392406,"name":"Gilad Ofek","orcid":"0000-0002-0677-4467","position":40,"is_corresponding":false},{"id":541515,"name":"B. Korber","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:22:15.958504Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}