{"doi":"10.17615/55bn-7729","title":"A New Tool Improves Diagnostic Test Performance for Transmission EM Evaluation of Axonemal Dynein Arms","abstract":"Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to diagnostic uncertainty even for experienced morphologists. We developed a novel image analysis tool to average the axonemal peripheral microtubular doublets, thereby increasing microtubular signal and reducing random background noise. In a randomized, double-blinded study that compared two experienced morphologists and three different diagnostic approaches, we found that use of this tool led to improvement in diagnostic TEM test performance.","journal":"UNC Libraries","year":2020,"id":142153,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":72635,"name":"William K. Funkhouser","orcid":null,"position":1,"is_corresponding":false},{"id":303535,"name":"Johnny L. Carson","orcid":null,"position":2,"is_corresponding":false},{"id":302579,"name":"Maimoona A. Zariwala","orcid":"0000-0003-1619-1393","position":3,"is_corresponding":false},{"id":393545,"name":"Margaret W. Leigh","orcid":"0000-0002-6420-2459","position":4,"is_corresponding":false},{"id":547662,"name":"Marc Niethammer","orcid":null,"position":5,"is_corresponding":false},{"id":302583,"name":"Michael R. Knowles","orcid":"0000-0002-4672-5969","position":7,"is_corresponding":false},{"id":545270,"name":"Kimberlie A. Burns","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:31.424593Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}