{"doi":"10.17615/54az-rn94","title":"Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/ let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas","abstract":"In cold-blooded vertebrates such as zebrafish, Müller glial cells (MGs) readily proliferate to replenish lost retinal neurons. In mammals, however, MGs lack regenerative capability as they do not spontaneously re-enter the cell cycle unless the retina is injured. Here, we show that gene transfer of β-catenin in adult mouse retinas activates Wnt signaling and MG proliferation without retinal injury. Upstream of Wnt, deletion of GSK3β stabilizes β-catenin and activates MG proliferation. Downstream of Wnt, β-catenin binds to the Lin28 promoter and activates transcription. Deletion of Lin28 abolishes β-catenin-mediated effects on MG proliferation, and Lin28 gene transfer stimulates MG proliferation. We further demonstrate that let-7 miRNAs are critically involved in Wnt/Lin28-regulated MG proliferation. Intriguingly, a subset of cell-cycle-reactivated MGs express markers for amacrine cells. Together, these results reveal a key role of Wnt-Lin28-let7 miRNA signaling in regulating proliferation and neurogenic potential of MGs in the adult mammalian retina.","journal":"UNC Libraries","year":2020,"id":138512,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235840,"name":"David V. Schaffer","orcid":"0000-0002-9625-0121","position":1,"is_corresponding":false},{"id":599955,"name":"Kai Yao","orcid":"0000-0001-8846-5184","position":2,"is_corresponding":false},{"id":393820,"name":"William D. Snider","orcid":null,"position":3,"is_corresponding":false},{"id":274377,"name":"John G. Flannery","orcid":"0000-0002-0720-8897","position":4,"is_corresponding":false},{"id":599956,"name":"Bo Chen","orcid":"0000-0001-5748-8551","position":5,"is_corresponding":false},{"id":599957,"name":"Lin Tian","orcid":"0000-0001-6281-1034","position":6,"is_corresponding":false},{"id":599954,"name":"Suo Qiu","orcid":"0000-0003-4913-2015","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:02.849477Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}