{"doi":"10.17615/53nk-1168","title":"Multidrug-Resistant Gram-Negative Bacteria in Burn Patients","abstract":"Patients with burn injuries are at high risk for infectious complications, and infections are the most common cause of death after the first 72 h of hospitalization. Hospital-acquired infections caused by multidrug resistant (MDR) Gram-negative bacteria (GNB) in this population are concerning. Here, we evaluated carriage with MDR GNB in patients in a large tertiary-care burn intensive care unit. Twenty-nine patients in the burn unit were screened for intestinal carriage. Samples were cultured on selective media. Median time from admission to the burn unit to first sample collection was 9 days (IQR 5 – 17 days). In 21 (72%) patients, MDR GNB were recovered; the most common bacterial species isolated was Pseudomonas aeruginosa, which was found in 11/29 (38%) of patients. Two of these patients later developed bloodstream infections with P. aeruginosa. Transmission of KPC-31-producing ST22 Citrobacter freundii was detected. Samples from two patients grew genetically similar C. freundii isolates that were resistant to ceftazidime-avibactam. On analysis of whole-genome sequencing, blaKPC-31 was part of a Tn4401b transposon that was present on two different plasmids in each C. freundii isolate. Plasmid curing experiments showed that removal of both copies of blaKPC-31 was required to restore susceptibility to ceftazidime-avibactam. In summary, MDR GNB colonization is common in burn patients and patient-to-patient transmission of highly resistant GNB occurs. These results emphasize the ongoing need for infection prevention and antimicrobial stewardship efforts in this highly vulnerable population.","journal":"UNC Libraries","year":2024,"id":498823,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9628,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":591393,"name":"L. Bartelt","orcid":null,"position":1,"is_corresponding":false},{"id":803112,"name":"Trey Kanumuambidi","orcid":null,"position":2,"is_corresponding":false},{"id":531549,"name":"Felicia Williams","orcid":"0000-0002-5483-2529","position":3,"is_corresponding":false},{"id":1320399,"name":"Bonomo R.A.","orcid":null,"position":4,"is_corresponding":false},{"id":1345883,"name":"Yen K.","orcid":null,"position":5,"is_corresponding":false},{"id":1345389,"name":"Enrica Sozzi","orcid":"0000-0002-0144-1217","position":6,"is_corresponding":false},{"id":1345762,"name":"Marshall S.H.","orcid":null,"position":7,"is_corresponding":false},{"id":255959,"name":"Dean G. Brown","orcid":"0000-0002-7130-3928","position":8,"is_corresponding":false},{"id":1275223,"name":"van Duin D.","orcid":null,"position":9,"is_corresponding":false},{"id":643703,"name":"Arash Naziripour","orcid":null,"position":10,"is_corresponding":false},{"id":1345884,"name":"Chu T.","orcid":null,"position":11,"is_corresponding":false},{"id":231558,"name":"Barry N. Kreiswirth","orcid":"0000-0002-0243-131X","position":12,"is_corresponding":false},{"id":717806,"name":"Laura Ruegsegger","orcid":"0000-0003-1511-4804","position":13,"is_corresponding":false},{"id":892845,"name":"Jinyu Xiao","orcid":"0000-0003-2318-313X","position":14,"is_corresponding":false},{"id":1323898,"name":"Rudin S.D.","orcid":null,"position":15,"is_corresponding":false},{"id":231557,"name":"Liang Chen","orcid":"0000-0001-5845-2235","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:42.181447Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}