{"doi":"10.17615/4n3k-1m67","title":"Prothoracicotropic Hormone Regulates Developmental Timing and Body Size in Drosophila","abstract":"In insects, control of body size is intimately linked to nutritional quality as well as environmental and genetic cues that regulate the timing of developmental transitions. Prothoracicotropic hormone (PTTH) has been proposed to play an essential role in regulating the production and/or release of ecdysone, a steroid hormone that stimulates molting and metamorphosis. In this report we examine the consequences on Drosophila development of ablating the PTTH-producing neurons. Surprisingly, PTTH production is not essential for molting or metamorphosis. Instead, loss of PTTH results in delayed larval development and eclosion of larger flies with more cells. Prolonged feeding, without changing the rate of growth, causes the developmental delay and is a consequence of low ecdysteroid titers. These results indicate that final body size in insects is determined by a balance between growth rate regulators such as insulin and developmental timing cues such as PTTH that set the duration of the feeding interval.","journal":"UNC Libraries","year":2020,"id":143738,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":611858,"name":"Robert B. Beckstead","orcid":"0000-0001-6827-0515","position":1,"is_corresponding":false},{"id":277581,"name":"Michael B. O’Connor","orcid":"0000-0002-3067-5506","position":2,"is_corresponding":false},{"id":611859,"name":"Jean-Philippe Parvy","orcid":"0000-0002-6643-5686","position":3,"is_corresponding":false},{"id":612231,"name":"Zofeyah McBrayer","orcid":null,"position":4,"is_corresponding":false},{"id":612232,"name":"Chantal Dauphin‐Villemant","orcid":null,"position":5,"is_corresponding":false},{"id":385109,"name":"Carl S. Thummel","orcid":"0000-0001-8112-4643","position":6,"is_corresponding":false},{"id":5716,"name":"James T. Warren","orcid":null,"position":7,"is_corresponding":false},{"id":611860,"name":"Hajime Ono","orcid":"0000-0001-8249-8225","position":8,"is_corresponding":false},{"id":174079,"name":"Lawrence I. Gilbert","orcid":null,"position":9,"is_corresponding":false},{"id":612230,"name":"MaryJane Shimell","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:17:41.821196Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}