{"doi":"10.17615/4e8j-ny33","title":"The Prevalence of Knee Symptoms, Radiographic, and Symptomatic Osteoarthritis at Four Time Points: The Johnston County Osteoarthritis Project, 1999-2018","abstract":"Objective: To describe point prevalence of knee symptoms, radiographic knee osteoarthritis (rKOA), severe rKOA, and symptomatic rKOA at four time points in the longitudinal, population-based Johnston County Osteoarthritis Project (JoCo OA). Methods: Data were from 2573 JoCo OA participants with up to 18 years of follow-up (1999-2018) and standardized fixed-flexion knee radiographs read by a single, reliable expert musculoskeletal radiologist. The four outcomes were 1) self-reported knee symptoms, defined by “On most days, do you have pain, aching, or stiffness in your right/left knee?”; 2) rKOA, defined as a Kellgren-Lawrence grade (KLG) of 2 to 4); 3) severe rKOA, defined as a KLG of 3 or 4; and 4) symptomatic rKOA, defined as both symptoms and rKOA in the same joint. Weighted prevalence estimates and 95% confidence intervals (CIs) were generated overall and by age group, sex, race, and body mass index (BMI). Results: Most recently (2017-2018, T4), the overall prevalence (percentage) of knee symptoms, rKOA, severe rKOA, and symptomatic rKOA was 41% (95% CI: 35-47%), 61% (95% CI: 56-67%), 35% (95% CI: 30-40%), and 30% (95% CI: 24-35%), respectively. From time point T1 to T4, prevalence increased for rKOA, severe rKOA, and symptomatic rKOA but not for knee symptoms. The prevalence of both severe rKOA (17-39%) and symptomatic rKOA (23-30%) was consistently higher among women. The prevalence of all outcomes was higher among those with higher BMI and among Black participants at all time points, particularly rKOA (35-69%) and severe rKOA (22-46%). Conclusion: These updated estimates demonstrate a large and increasing burden of knee OA, particularly among women and Black individuals.","journal":"UNC Libraries","year":2023,"id":412589,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8909,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":433978,"name":"Louise B. Murphy","orcid":"0000-0003-3919-0721","position":1,"is_corresponding":false},{"id":433984,"name":"Charles G. Helmick","orcid":"0000-0001-5036-8215","position":2,"is_corresponding":false},{"id":509635,"name":"Carolina Álvarez","orcid":"0000-0003-1409-0898","position":3,"is_corresponding":false},{"id":528888,"name":"Jordan B. Renner","orcid":"0000-0003-2137-3052","position":4,"is_corresponding":false},{"id":383773,"name":"Yvonne M. Golightly","orcid":"0000-0003-1205-2759","position":5,"is_corresponding":false},{"id":1193749,"name":"R.J. Cleveland","orcid":null,"position":6,"is_corresponding":false},{"id":318561,"name":"Joanne M. Jordan","orcid":"0000-0003-2469-9955","position":7,"is_corresponding":false},{"id":528934,"name":"Todd A. Schwartz","orcid":"0000-0002-0232-2543","position":8,"is_corresponding":false},{"id":416071,"name":"David Hu","orcid":"0000-0001-9306-4705","position":9,"is_corresponding":false},{"id":414465,"name":"Liubov Arbeeva","orcid":"0000-0001-5004-419X","position":10,"is_corresponding":false},{"id":331494,"name":"Amanda E. Nelson","orcid":"0000-0002-9344-7877","position":11,"is_corresponding":false},{"id":333486,"name":"Leigh F. Callahan","orcid":"0000-0001-6362-7220","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:21:50.261851Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}