{"doi":"10.17615/4azs-8p30","title":"Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika","abstract":"Little is known about enduring memory B cell (MBC) responses to Zika virus (ZIKV) and their relationship with circulating antibodies. Here we comprehensively assess MBC frequency and specificity alongside serum binding and neutralizing antibody responses to ZIKV ~2 weeks and ~8 months postinfection in 31 pediatric subjects with 0, 1 or >1 prior infections with the related dengue virus (DENV). ZIKV infection elicits a robust type-specific MBC response, and the majority of late convalescent anti-ZIKV serum neutralizing activity is attributable to ZIKV-specific antibodies. The number of prior DENV infections does not influence type-specific or cross-reactive MBC responses, although ZIKV has the highest cross-reactivity with DENV3. DENV cross-reactive MBCs expanded by ZIKV infection decline in number and proportion by late convalescence. Finally, ZIKV induces greater cross-reactivity in the MBC pool than in serum antibodies. Our data suggest immunity to DENV only modestly shapes breadth and magnitude of enduring ZIKV antibody responses.","journal":"UNC Libraries","year":2020,"id":117206,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":547363,"name":"M. Montoya","orcid":null,"position":1,"is_corresponding":false},{"id":547364,"name":"M. Collins","orcid":null,"position":2,"is_corresponding":false},{"id":515736,"name":"E. Harris","orcid":null,"position":3,"is_corresponding":false},{"id":547365,"name":"G. Kuan","orcid":null,"position":4,"is_corresponding":false},{"id":547366,"name":"L.C. Katzelnick","orcid":null,"position":5,"is_corresponding":false},{"id":547367,"name":"Paolo Marinho De Andrade","orcid":null,"position":6,"is_corresponding":false},{"id":547368,"name":"C. Gimblet-Ochieng","orcid":null,"position":7,"is_corresponding":false},{"id":547369,"name":"A. Balmaseda","orcid":null,"position":8,"is_corresponding":false},{"id":547370,"name":"F. Modirian","orcid":null,"position":9,"is_corresponding":false},{"id":399572,"name":"De Silva","orcid":"0000-0001-7535-141X","position":10,"is_corresponding":false},{"id":546730,"name":"Mairelin Delia Chirinos Cárdenas","orcid":"0000-0001-5270-8797","position":11,"is_corresponding":false},{"id":547371,"name":"D. Michlmayr","orcid":null,"position":12,"is_corresponding":false},{"id":547362,"name":"J. Coloma","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:13:51.309289Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}