{"doi":"10.17615/48dn-p307","title":"Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection","abstract":"The key to battling the COVID-19 pandemic and its potential aftermath is to develop a variety of vaccines that are efficacious and safe, elicit lasting immunity, and cover a range of SARS-CoV-2 variants. Recombinant viral receptor-binding domains (RBDs) are safe vaccine candidates but often have limited efficacy due to the lack of virus-like immunogen display pattern. Here we have developed a novel virus-like nanoparticle (VLP) vaccine that displays 120 copies of SARS-CoV-2 RBD on its surface. This VLP-RBD vaccine mimics virus-based vaccines in immunogen display, which boosts its efficacy, while maintaining the safety of protein-based subunit vaccines. Compared to the RBD vaccine, the VLP-RBD vaccine induced five times more neutralizing antibodies in mice that efficiently blocked SARSCoV- 2 from attaching to its host receptor and potently neutralized the cell entry of variant SARS-CoV-2 strains, SARS-CoV-1, and SARS-CoV-1-related bat coronavirus. These neutralizing immune responses induced by the VLP-RBD vaccine did not wane during the twomonth study period. Furthermore, the VLP-RBD vaccine effectively protected mice from SARS-CoV-2 challenge, dramatically reducing the development of clinical signs and pathological changes in immunized mice. The VLP-RBD vaccine provides one potentially effective solution to controlling the spread of SARS-CoV-2.","journal":"UNC Libraries","year":2021,"id":208752,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":565762,"name":"Jian Shang","orcid":"0000-0001-5135-6574","position":1,"is_corresponding":false},{"id":333823,"name":"Sharon Taft-Benz","orcid":"0000-0002-0965-8760","position":2,"is_corresponding":false},{"id":103760,"name":"Qibin Geng","orcid":"0000-0003-4872-2400","position":3,"is_corresponding":false},{"id":105500,"name":"Kenneth H. Dinnon","orcid":"0000-0002-8942-1551","position":4,"is_corresponding":false},{"id":134869,"name":"Victoria K. Baxter","orcid":"0000-0003-0916-360X","position":5,"is_corresponding":false},{"id":318063,"name":"Marc K. Jenkins","orcid":"0000-0001-8009-7655","position":6,"is_corresponding":false},{"id":105111,"name":"Sarah R. Leist","orcid":"0000-0002-4989-5381","position":7,"is_corresponding":false},{"id":103706,"name":"Fang Li","orcid":"0000-0002-1958-366X","position":8,"is_corresponding":false},{"id":795409,"name":"Juan Shi","orcid":"0000-0003-2652-8084","position":9,"is_corresponding":false},{"id":105104,"name":"Xiujuan Zhang","orcid":"0000-0002-5312-0909","position":10,"is_corresponding":false},{"id":795877,"name":"Langying Du","orcid":null,"position":11,"is_corresponding":false},{"id":275061,"name":"Mark T. Heise","orcid":"0000-0001-5829-8477","position":12,"is_corresponding":false},{"id":105115,"name":"Stephanie A. Montgomery","orcid":"0000-0001-8012-5302","position":13,"is_corresponding":false},{"id":255554,"name":"Wanbo Tai","orcid":"0000-0002-9864-8993","position":14,"is_corresponding":false},{"id":103703,"name":"Yushun Wan","orcid":"0000-0003-0496-6315","position":15,"is_corresponding":false},{"id":311644,"name":"Elizabeth J. Anderson","orcid":"0000-0002-9137-6518","position":16,"is_corresponding":false},{"id":218437,"name":"Chien‐Te K. Tseng","orcid":"0000-0001-5726-9834","position":17,"is_corresponding":false},{"id":423586,"name":"Audrey C. Knight","orcid":"0000-0002-8009-8081","position":18,"is_corresponding":false},{"id":5952,"name":"Ralph S. Baric","orcid":"0000-0001-6827-8701","position":19,"is_corresponding":false},{"id":255555,"name":"Aleksandra Drelich","orcid":"0000-0002-0201-5017","position":20,"is_corresponding":false},{"id":795876,"name":"Sung-Wook Hon","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:51:57.582057Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}