{"doi":"10.17615/42t3-k441","title":"Synergy of Nitric Oxide and Silver Sulfadiazine against Gram-Negative, Gram-Positive, and Antibiotic-Resistant Pathogens","abstract":"The synergistic activity between nitric oxide (NO) released from diazeniumdiolate-modified proline (PROLI/NO) and silver (I) sulfadiazine (AgSD) was evaluated against Escherichia coli, Enterococcus faecalis, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis using a modified broth microdilution technique and a checkerboard-type assay. The combination of NO and AgSD was defined as synergistic when the fractional bactericidal concentration (FBC) was calculated to be <0.5 Gram-negative species were generally more susceptible to the individual antimicrobial agents than the Gram-positive bacteria. The in vitro synergistic activity of AgSD and NO observed against a range of pathogens strongly supports future investigation of this therapeutic combination, particularly for its potential use in the treatment of chronic and burn wounds.","journal":"UNC Libraries","year":2020,"id":139225,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":547908,"name":"Peter N. Coneski","orcid":null,"position":1,"is_corresponding":false},{"id":266943,"name":"Kavitha S. Rao","orcid":"0000-0001-5401-6989","position":2,"is_corresponding":false},{"id":394496,"name":"Mark H. Schoenfisch","orcid":"0000-0002-2212-0658","position":3,"is_corresponding":false},{"id":593367,"name":"Christopher Johnson","orcid":"0000-0003-1255-8207","position":4,"is_corresponding":false},{"id":534387,"name":"Benjamin J. Privett","orcid":null,"position":5,"is_corresponding":false},{"id":602537,"name":"Christopher J. Backlund","orcid":null,"position":6,"is_corresponding":false},{"id":602536,"name":"Susan M. Deupree","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:10.185988Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}