{"doi":"10.17615/3x72-r254","title":"A Prospective, Randomized, Multicenter Trial Assessing a Novel Lysine-Derived Urethane Adhesive in a Large Flap Surgical Procedure without Drains","abstract":"Objective To evaluate the safety and effectiveness of a lysine-derived urethane adhesive as a noninvasive alternative to closed suction drains in a commonly performed large flap surgical procedure.MethodsOne hundred thirty subjects undergoing abdominoplasty at five centers were prospectively randomized to standard flap closure with surgical drains (Control group) or a lysine-derived urethane adhesive (Treatment group) without drains. The primary outcome measured was the number of post-operative procedures, including drain removals (as the event marking the use of a surgical drain) and needle aspirations. Secondary endpoints included total wound drainage, cumulative days of treatment, and days to drain removal. A patient questionnaire evaluating quality of life measures was also administered.ResultsSubjects in the Treatment group required significantly fewer post-operative procedures compared to the Control group (1.8±3.8 vs. 2.4±1.2 procedures; p<0.0001) and fewer cumulative days of treatment (1.6±0.4 vs. 7.3±3.3; p<0.0001). A procedure to address fluid accumulation was required for only 27.3% of the subjects in the Treatment group versus 100% of Control group, which by study design required the use of drains. The mean duration of use of indwelling surgical drains for the Control group was 6.9±3.3days. All fluid collections treated with percutaneous aspiration were resolved and there were no unanticipated adverse events.ConclusionThe results of the study support that the use of a lysine-derived urethane adhesive is a safe and effective alternative to drains in patients undergoing a common large flap surgical procedure.Level of Evidence IThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.","journal":"UNC Libraries","year":2020,"id":117724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9374,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":549053,"name":"Sheri Slezak","orcid":null,"position":1,"is_corresponding":false},{"id":548394,"name":"Joseph P. Hunstad","orcid":"0000-0002-0455-046X","position":2,"is_corresponding":false},{"id":549054,"name":"Joseph J. Michaels","orcid":null,"position":3,"is_corresponding":false},{"id":409148,"name":"J. Peter Rubin","orcid":"0000-0003-2040-6051","position":4,"is_corresponding":false},{"id":549055,"name":"A. Jay Burns","orcid":null,"position":5,"is_corresponding":false},{"id":549056,"name":"Dottie M. Clower","orcid":null,"position":6,"is_corresponding":false},{"id":549052,"name":"W. Grant Stevens","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:13:54.951170Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}