{"doi":"10.17615/3g4m-8t32","title":"Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension","abstract":"Vascular injury and remodeling are common pathological sequelae of hypertension. Previous studies have suggested that the renin-angiotensin system (RAS) acting through the type I (AT1) angiotensin (AT1)-receptor promotes vascular pathology in hypertension. To study the role of AT1-receptors in this process, we generated mice with cell-specific deletion of AT1-receptors in VSMCs using Cre/Loxp technology. We crossed the SM22α-Cre transgenic mouse line expressing Cre recombinase in smooth muscle cells with a mouse line bearing a conditional allele of the Agtr1a gene (Agtr1a flox), encoding the major murine AT1-receptor isoform (AT1A). In SM22α-Cre+Agtr1a flox/flox (SMKO) mice, AT1A-receptors were efficiently deleted from VSMCs in larger vessels, but not from resistance vessels such as pre-glomerular arterioles. Thus, vasoconstrictor responses to angiotensin II were preserved in SMKOs. To induce hypertensive vascular remodeling, mice were continuously infused with angiotensin II for 4 weeks. During infusion of angiotensin II, blood pressures increased significantly and to a similar extent in SMKOs and controls. In control mice, there was evidence of vascular oxidative stress indicated by enhanced nitrated tyrosine residues in segments of aorta; this was significantly attenuated in SMKOs. Despite these differences in oxidative stress, the extent of aortic medial expansion induced by angiotensin II infusion was virtually identical in both groups. Thus, vascular AT1A-receptors promote oxidative stress in the aortic wall but are not required for remodeling in angiotensin II-dependent hypertension.","journal":"UNC Libraries","year":2020,"id":142647,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9582,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":290796,"name":"Timothy Haystead","orcid":"0000-0001-7274-1519","position":1,"is_corresponding":false},{"id":610216,"name":"J. Snouwaert","orcid":null,"position":2,"is_corresponding":false},{"id":440989,"name":"A. Vivekanandan-Giri","orcid":null,"position":3,"is_corresponding":false},{"id":610217,"name":"C. N. Fortner","orcid":null,"position":4,"is_corresponding":false},{"id":610218,"name":"K. K. Parsons","orcid":null,"position":5,"is_corresponding":false},{"id":538618,"name":"B. Koller","orcid":null,"position":6,"is_corresponding":false},{"id":610219,"name":"J. Stegbauer","orcid":null,"position":7,"is_corresponding":false},{"id":523179,"name":"S. B. Gurley","orcid":null,"position":8,"is_corresponding":false},{"id":610220,"name":"R. C. GRIFFITHS","orcid":null,"position":9,"is_corresponding":false},{"id":610221,"name":"T. H. Le","orcid":null,"position":10,"is_corresponding":false},{"id":522795,"name":"T. M. Coffman","orcid":null,"position":11,"is_corresponding":false},{"id":610222,"name":"E. W. Raasch","orcid":null,"position":12,"is_corresponding":false},{"id":440979,"name":"S. Pennathur","orcid":null,"position":13,"is_corresponding":false},{"id":610215,"name":"M. A. Sparks","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:34.768426Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}