{"doi":"10.17615/3fa9-vh68","title":"Circulating short-chain fatty acids are positively associated with adiposity measures in chinese adults","abstract":"Epidemiological studies suggest a positive association between obesity and fecal short-chain fatty acids (SCFAs) produced by microbial fermentation of dietary carbohydrates, while animal models suggest increased energy harvest through colonic SCFA production in obesity. However, there is a lack of human population-based studies with dietary intake data, plasma SCFAs, gut microbial, and anthropometric data. In 490 Chinese adults aged 30–68 years, we examined the associations between key plasma SCFAs (butyrate/isobutyrate, isovalerate, and valerate measured by non-targeted plasma metabolomics) with body mass index (BMI) using multivariable-adjusted linear regression. We then assessed whether overweight (BMI ≥ 24 kg/m2 ) modified the association between dietary-precursors of SCFAs (insoluble fiber, total carbohydrates, and high-fiber foods) with plasma SCFAs. In a sub-sample (n = 209) with gut metagenome data, we examined the association between gut microbial SCFA-producers with BMI. We found positive associations between butyrate/isobutyrate and BMI (p-value < 0.05). The associations between insoluble fiber and butyrate/isobutyrate differed by overweight (p-value < 0.10). There was no statistical evidence for an association between microbial SCFA-producers and BMI. In sum, plasma SCFAs were positively associated with BMI and that the colonic fermentation of fiber may differ for adults with versus without overweight.","journal":"UNC Libraries","year":2022,"id":295602,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":214360,"name":"H. WANG","orcid":null,"position":1,"is_corresponding":false},{"id":835090,"name":"A.A. Fodor","orcid":null,"position":2,"is_corresponding":false},{"id":835083,"name":"M.C.B. Tsilimigras","orcid":null,"position":3,"is_corresponding":false},{"id":970694,"name":"W. Sha","orcid":null,"position":4,"is_corresponding":false},{"id":10783,"name":"J. Zhang","orcid":"0000-0002-4380-1655","position":5,"is_corresponding":false},{"id":837655,"name":"A.G. Howard","orcid":null,"position":6,"is_corresponding":false},{"id":573664,"name":"Y. Wang","orcid":"0000-0001-9849-0682","position":7,"is_corresponding":false},{"id":981850,"name":"S. Sun","orcid":null,"position":8,"is_corresponding":false},{"id":981851,"name":"K.A. Meyer","orcid":null,"position":9,"is_corresponding":false},{"id":144481,"name":"Zhihong Wang","orcid":null,"position":10,"is_corresponding":false},{"id":533871,"name":"P. Gordon-Larsen","orcid":null,"position":11,"is_corresponding":false},{"id":200596,"name":"C. Su","orcid":null,"position":12,"is_corresponding":false},{"id":981852,"name":"Binzhe Zhang","orcid":null,"position":13,"is_corresponding":false},{"id":274762,"name":"Christy L. Avery","orcid":"0000-0002-1044-8162","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:31:08.861377Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}