{"doi":"10.17615/36vv-pp55","title":"Comparison of Hepatitis B Virus Infection in HIV-Infected and HIV-Uninfected Participants Enrolled in a Multinational Clinical Trial: HPTN 052","abstract":"Objective: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(2)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multinational clinical trial: HIV Prevention Trials Network (HPTN 052). Method: HBV infection status at enrollment was compared between HIV(+) (N = 1241) and HIV(-) (N = 1232) from 7 HBV-endemic countries. Hepatitis B e antigen and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with x2 Fisher exact and median tests. Results: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, \"HBcAb\"; 24.7% HBcAb and anti-HB surface antibody positive, \"recovered\"), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(2) except for isolated HBcAb, which was more prevalent in HIV(+) than HIV(2) [10.1% vs. 7.7%, P = 0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(2). In HIV (+) with cHB versus those without cHB, transaminase elevations were more prevalent (alanine aminotransferase # grade 2, 12% vs. 5.2%, P = 0.037; aspartate aminotransferase # grade 2, 26% vs. 6.0%, P, 0.001), CD4 trended lower, and HIV RNA was similar. Conclusions: HBV infection status did not differ by HIV infection status. HIV co-infection was associated with isolated HBcAb and a trend of increased HBV DNA. In HIV, cHB was associated with mild transaminase elevations and a trend toward lower CD4.","journal":"UNC Libraries","year":2023,"id":415757,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":531556,"name":"San‐San Ou","orcid":"0000-0002-9213-6997","position":1,"is_corresponding":false},{"id":609570,"name":"R. 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Gamble","orcid":null,"position":12,"is_corresponding":false},{"id":609584,"name":"M. McCauley","orcid":null,"position":13,"is_corresponding":false},{"id":1198053,"name":"J. Makhema","orcid":null,"position":14,"is_corresponding":false},{"id":1198059,"name":"M.G. De Melo","orcid":null,"position":15,"is_corresponding":false},{"id":1198152,"name":"Cholticha Ruangyuttikarn","orcid":null,"position":16,"is_corresponding":false},{"id":597931,"name":"M.S. Cohen","orcid":null,"position":17,"is_corresponding":false},{"id":547657,"name":"S.H. Eshleman","orcid":null,"position":18,"is_corresponding":false},{"id":1198153,"name":"Allen E. Greer","orcid":null,"position":19,"is_corresponding":false},{"id":595784,"name":"N. Kumarasamy","orcid":null,"position":20,"is_corresponding":false},{"id":533758,"name":"M.C. Hosseinipour","orcid":null,"position":21,"is_corresponding":false},{"id":591620,"name":"B. Grinsztejn","orcid":null,"position":22,"is_corresponding":false},{"id":1198154,"name":"V. Akelo","orcid":null,"position":23,"is_corresponding":false},{"id":1077120,"name":"Elizabeth Wilson","orcid":"0000-0001-6644-1392","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:22:15.958504Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}