{"doi":"10.17615/2tyg-me06","title":"Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection","abstract":"The antibody response to HIV-1 does not appear in the plasma until approximately 2–5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks or more after transmission. Moreover, levels of HIV-1–specific antibodies decline on antiretroviral treatment. The mechanisms of this delay in the appearance of anti-HIV-1 antibodies and of their subsequent rapid decline are not known. While the effect of HIV-1 on depletion of gut CD4+ T cells in acute HIV-1 infection is well described, we studied blood and tissue B cells soon after infection to determine the effect of early HIV-1 on these cells.","journal":"UNC Libraries","year":2020,"id":139693,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9451,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":343908,"name":"Nathan Vandergrift","orcid":"0000-0001-9994-5466","position":1,"is_corresponding":false},{"id":292261,"name":"Hua‐Xin Liao","orcid":"0000-0002-7871-1334","position":2,"is_corresponding":false},{"id":280549,"name":"Kwan‐Ki Hwang","orcid":"0000-0002-3903-6997","position":3,"is_corresponding":false},{"id":603770,"name":"Daniel C. Parker","orcid":null,"position":4,"is_corresponding":false},{"id":253820,"name":"George M. Shaw","orcid":"0000-0002-2338-4532","position":5,"is_corresponding":false},{"id":258351,"name":"Georgia D. Tomaras","orcid":"0000-0001-8076-1931","position":6,"is_corresponding":false},{"id":603254,"name":"Sallie D. Allgood","orcid":"0000-0002-0329-4572","position":7,"is_corresponding":false},{"id":392407,"name":"Barton F. Haynes","orcid":"0000-0002-2847-1854","position":8,"is_corresponding":false},{"id":603771,"name":"John F. Whitesides","orcid":null,"position":9,"is_corresponding":false},{"id":603772,"name":"Joshua D. Amos","orcid":null,"position":10,"is_corresponding":false},{"id":240555,"name":"Paul Goepfert","orcid":"0000-0001-8441-5737","position":11,"is_corresponding":false},{"id":603773,"name":"Benjamin B. Haynes","orcid":null,"position":12,"is_corresponding":false},{"id":603774,"name":"Dawn J. Marshall","orcid":null,"position":13,"is_corresponding":false},{"id":280566,"name":"Garnett Kelsoe","orcid":"0000-0002-8770-040X","position":14,"is_corresponding":false},{"id":603255,"name":"Jörn E. Schmitz","orcid":"0000-0001-8803-0922","position":15,"is_corresponding":false},{"id":105520,"name":"David M. Margolis","orcid":"0000-0001-5714-0002","position":16,"is_corresponding":false},{"id":603256,"name":"Marc C. Levesque","orcid":"0000-0001-7398-5136","position":17,"is_corresponding":false},{"id":524565,"name":"Charles B. Hicks","orcid":null,"position":18,"is_corresponding":false},{"id":327482,"name":"Thaddeus C. Gurley","orcid":null,"position":19,"is_corresponding":false},{"id":32982,"name":"M. Anthony Moody","orcid":null,"position":20,"is_corresponding":false},{"id":603775,"name":"Steven G. Plonk","orcid":null,"position":21,"is_corresponding":false},{"id":524564,"name":"Martin Markowitz","orcid":null,"position":22,"is_corresponding":false},{"id":365133,"name":"Nicholas J. Shaheen","orcid":"0000-0001-6602-5647","position":23,"is_corresponding":false},{"id":249712,"name":"Myron S. Cohen","orcid":"0000-0001-5917-9664","position":24,"is_corresponding":false},{"id":249713,"name":"Joseph J. Eron","orcid":"0000-0002-4938-0644","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:17:13.583586Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}